新型环脂肽LY146032对棒状杆菌属细菌的体外活性比较

Comparative in vitro activity of the new cyclic lipopeptide LY146032 against Corynebacterium species.

作者信息

Spitzer P G, Eliopoulos G M, Karchmer A W, Moellering R C

出版信息

Eur J Clin Microbiol. 1987 Apr;6(2):183-5. doi: 10.1007/BF02018205.

DOI:10.1007/BF02018205

Abstract

Agar dilution and time-kill techniques were used to assess the in vitro activity of LY146032 and several other antibacterial agents against Corynebacterium spp. The activity of LY146032 was similar to that of vancomycin and teicoplanin. Synergistic killing by a combination of LY146032 and gentamicin could be demonstrated under certain carefully controlled conditions.

摘要

采用琼脂稀释法和杀菌动力学方法评估LY146032及其他几种抗菌药物对棒状杆菌属的体外活性。LY146032的活性与万古霉素和替考拉宁相似。在某些严格控制的条件下，可证明LY146032与庆大霉素联合使用具有协同杀菌作用。