具有抗血管生成和抗炎作用的红树树叶和小枝成分。
Components from the Leaves and Twigs of Mangrove with Anti-Angiogenic and Anti-Inflammatory Effects.
机构信息
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.
出版信息
Mar Drugs. 2018 Oct 25;16(11):404. doi: 10.3390/md16110404.
One new neolignan, racelactone A (), together with seven known compounds (-) were isolated from the methanolic extract of the leaves and twigs of . The structure of racelactone A () was determined on the basis of the mass and NMR spectroscopic data interpretation. With respect to bioactivity, compound 1 displayed an anti-angiogenic effect by suppressing tube formation. Furthermore, compounds , , and showed significant anti-inflammatory effects with IC values of 4.95 ± 0.89, 1.95 ± 0.40, and 2.57 ± 0.23 M, respectively. The plausible biosynthesis pathway of racelactone A () was proposed.
从 的叶和枝的甲醇提取物中分离得到一个新的苯丙素类化合物（），以及七个已知化合物（-）。根据质谱和 NMR 光谱数据的解析，确定了 racelaCtone A () 的结构。在生物活性方面，化合物 1 通过抑制管形成显示出抗血管生成作用。此外，化合物 1、3 和 5 表现出显著的抗炎作用，IC 值分别为 4.95 ± 0.89、1.95 ± 0.40 和 2.57 ± 0.23 M。提出了 racelaCtone A () 的可能生物合成途径。
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