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具有抗血管生成和抗炎作用的红树树叶和小枝成分。

Components from the Leaves and Twigs of Mangrove with Anti-Angiogenic and Anti-Inflammatory Effects.

机构信息

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Department of Medicine, Mackay Medical College, New Taipei City 252, Taiwan.

出版信息

Mar Drugs. 2018 Oct 25;16(11):404. doi: 10.3390/md16110404.

DOI:10.3390/md16110404
PMID:30366373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6267291/
Abstract

One new neolignan, racelactone A (), together with seven known compounds (-) were isolated from the methanolic extract of the leaves and twigs of . The structure of racelactone A () was determined on the basis of the mass and NMR spectroscopic data interpretation. With respect to bioactivity, compound 1 displayed an anti-angiogenic effect by suppressing tube formation. Furthermore, compounds , , and showed significant anti-inflammatory effects with IC values of 4.95 ± 0.89, 1.95 ± 0.40, and 2.57 ± 0.23 M, respectively. The plausible biosynthesis pathway of racelactone A () was proposed.

摘要

从 的叶和枝的甲醇提取物中分离得到一个新的苯丙素类化合物（），以及七个已知化合物（-）。根据质谱和 NMR 光谱数据的解析，确定了 racelaCtone A () 的结构。在生物活性方面，化合物 1 通过抑制管形成显示出抗血管生成作用。此外，化合物 1、3 和 5 表现出显著的抗炎作用，IC 值分别为 4.95 ± 0.89、1.95 ± 0.40 和 2.57 ± 0.23 M。提出了 racelaCtone A () 的可能生物合成途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19b/6267291/f8784c026f7a/marinedrugs-16-00404-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19b/6267291/ebd089f2b976/marinedrugs-16-00404-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19b/6267291/a86064fda597/marinedrugs-16-00404-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19b/6267291/00cc8b253b66/marinedrugs-16-00404-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19b/6267291/f8784c026f7a/marinedrugs-16-00404-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19b/6267291/ebd089f2b976/marinedrugs-16-00404-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19b/6267291/a86064fda597/marinedrugs-16-00404-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19b/6267291/00cc8b253b66/marinedrugs-16-00404-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a19b/6267291/f8784c026f7a/marinedrugs-16-00404-g004.jpg

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2
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Molecules. 2015 Dec 11;20(12):22157-69. doi: 10.3390/molecules201219829.
3
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4
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Mar Drugs. 2022 Dec 27;21(1):22. doi: 10.3390/md21010022.
从扇叶诃子叶提取物中分离及鉴定抗菌化合物。
J Ethnopharmacol. 2014 Oct 28;156:228-34. doi: 10.1016/j.jep.2014.09.003. Epub 2014 Sep 16.
4
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5
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6
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7
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8
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Evid Based Complement Alternat Med. 2013;2013:943187. doi: 10.1155/2013/943187. Epub 2013 Jun 6.
9
Propofol inhibits superoxide production, elastase release, and chemotaxis in formyl peptide-activated human neutrophils by blocking formyl peptide receptor 1.异丙酚通过阻断甲酰肽受体 1 抑制甲酰肽激活的人中性粒细胞中超氧化物的产生、弹性蛋白酶释放和趋化性。
J Immunol. 2013 Jun 15;190(12):6511-9. doi: 10.4049/jimmunol.1202215. Epub 2013 May 13.
10
Hepatoprotective and antioxidant activity of a mangrove plant Lumnitzera racemosa.红树植物总序卤蕨的保肝和抗氧化活性
Asian Pac J Trop Biomed. 2011 Oct;1(5):348-52. doi: 10.1016/S2221-1691(11)60078-6.