小鼠乳酸脱氢酶-A功能基因的完整核苷酸序列：脱氢酶基因外显子-内含子结构的比较
Complete nucleotide sequence of the mouse lactate dehydrogenase-A functional gene: comparison of the exon-intron organization of dehydrogenase genes.
作者信息
Fukasawa K M, Li S S
出版信息
Genetics. 1987 May;116(1):99-105. doi: 10.1093/genetics/116.1.99.
Abstract
The complete sequence of 12,851 nucleotides of the mouse lactate dehydrogenase-A (LDH-A) gene has been determined. It includes eight exons, seven introns, promoter and regulatory regions. The B1 repetitive elements present in intron III and VI are oriented in opposite orientation, and they share 72% sequence homology. The exon-intron organization of mouse LDH-A gene is compared with the organizations of other dehydrogenase genes, and the molecular evolution of the nicotinamide adenine dinucleotide binding domains is discussed.
摘要
已确定小鼠乳酸脱氢酶 -A（LDH-A）基因12,851个核苷酸的完整序列。它包括八个外显子、七个内含子、启动子和调控区域。内含子III和VI中存在的B1重复元件方向相反，它们具有72%的序列同源性。将小鼠LDH-A基因的外显子 - 内含子组织与其他脱氢酶基因的组织进行了比较，并讨论了烟酰胺腺嘌呤二核苷酸结合域的分子进化。
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