Department of Pediatrics and Child Health, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Sci Rep. 2018 Oct 26;8(1):15879. doi: 10.1038/s41598-018-34342-6.
Adding vigorous-intensity intervals (VII) to moderate-intensity exercise prevents immediate declines in blood glucose in type 1 diabetes (T1D) however the intensity required to minimize post-exercise hypoglycemia is unknown. To examine this question, ten sedentary T1D individuals completed four treadmill exercise sessions: a control session of 45 minutes of walking at 45-55% of heart rate reserve (HRR) and three sessions consisting of 60 seconds (VII) at 70%, 80%, or 90% of HRR every 4 minutes during exercise at 45-55% of HRR. We used continuous glucose monitoring (CGM) to measure time ≤3.9 mmol/L, glucose variability, hypoglycemia frequency and area under the curve (AUC) for hypoglycemia and hyperglycemia for 12 hours post-exercise. We also examined growth hormone and cortisol responses during and following exercise. In the 12 hours post-exercise, the percentage of time ≤3.9 mmol/L, glucose variability, and AUC for hypoglycemia and hyperglycemia were similar across conditions. The frequency of hypoglycemic events was highest after the 90% intervals compared to the control arm (12 vs 3 events, p = 0.03). There was a trend towards elevated growth hormone with increasing exercise intensity but cortisol levels were similar across conditions. Adding VII to moderate intensity exercise may increase hypoglycemia risk at higher intensities.
在 1 型糖尿病（T1D）中，增加高强度间歇训练（VII）到中等强度运动可以防止血糖立即下降，但预防运动后低血糖所需的强度尚不清楚。为了研究这个问题，10 名久坐的 T1D 个体完成了四项跑步机运动：控制组是 45-55%的心率储备（HRR）的 45 分钟步行，三组分别是在 45-55%的 HRR 下运动时，每 4 分钟进行 60 秒（VII），强度分别为 70%、80%或 90%的 HRR。我们使用连续血糖监测（CGM）来测量运动后 12 小时内 ≤3.9mmol/L 的时间、血糖变异性、低血糖频率和低血糖及高血糖曲线下面积（AUC）。我们还检查了运动期间和之后生长激素和皮质醇的反应。在运动后 12 小时内，≤3.9mmol/L 的时间、血糖变异性和低血糖及高血糖 AUC 在不同条件下相似。与对照组相比，90%间隔后的低血糖事件频率最高（12 次与 3 次事件，p=0.03）。随着运动强度的增加，生长激素有升高的趋势，但皮质醇水平在不同条件下相似。在中等强度运动中增加 VII 可能会增加更高强度的低血糖风险。
