• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Adipose-derived mesenchymal stem cells treatments for fibroblasts of fibrotic scar via downregulating TGF-β1 and Notch-1 expression enhanced by photobiomodulation therapy.

作者信息

Han Bing, Fan Jincai, Liu Liqiang, Tian Jia, Gan Cheng, Yang Zengjie, Jiao Hu, Zhang Tiran, Liu Zheng, Zhang Hua

机构信息

Ninth Department of Plastic Surgery, Plastic Surgery Hospital of Chinese Academy of Medical Sciences, No. 33, Ba-Da-Chu Road, Beijing, China.

出版信息

Lasers Med Sci. 2019 Feb;34(1):1-10. doi: 10.1007/s10103-018-2567-9. Epub 2018 Oct 26.

DOI:10.1007/s10103-018-2567-9
PMID:30367294
Abstract
摘要

相似文献

1
Adipose-derived mesenchymal stem cells treatments for fibroblasts of fibrotic scar via downregulating TGF-β1 and Notch-1 expression enhanced by photobiomodulation therapy.脂肪间充质干细胞通过下调转化生长因子-β1和Notch-1表达对纤维化瘢痕成纤维细胞进行治疗，光生物调节疗法可增强该治疗效果。
Lasers Med Sci. 2019 Feb;34(1):1-10. doi: 10.1007/s10103-018-2567-9. Epub 2018 Oct 26.
2
Bone marrow derived mesenchymal stem cells inhibit the proliferative and profibrotic phenotype of hypertrophic scar fibroblasts and keloid fibroblasts through paracrine signaling.骨髓间充质干细胞通过旁分泌信号传导抑制增生性瘢痕成纤维细胞和瘢痕疙瘩成纤维细胞的增殖和促纤维化表型。
J Dermatol Sci. 2016 Aug;83(2):95-105. doi: 10.1016/j.jdermsci.2016.03.003. Epub 2016 Mar 4.
3
Adipose tissue-derived stromal cells inhibit TGF-β1-induced differentiation of human dermal fibroblasts and keloid scar-derived fibroblasts in a paracrine fashion.脂肪组织来源的基质细胞以旁分泌方式抑制转化生长因子-β1诱导的人皮肤成纤维细胞和瘢痕疙瘩来源的成纤维细胞分化。
Plast Reconstr Surg. 2014 Oct;134(4):699-712. doi: 10.1097/PRS.0000000000000504.
4
Human adipose tissue-derived stem cells inhibit the activity of keloid fibroblasts and fibrosis in a keloid model by paracrine signaling.人脂肪组织来源的干细胞通过旁分泌信号传导抑制瘢痕疙瘩模型中瘢痕疙瘩成纤维细胞的活性和纤维化。
Burns. 2018 Mar;44(2):370-385. doi: 10.1016/j.burns.2017.08.017. Epub 2017 Oct 10.
5
Inhibition of Pathological Phenotype of Hypertrophic Scar Fibroblasts Via Coculture with Adipose-Derived Stem Cells.脂肪源干细胞共培养抑制增生性瘢痕成纤维细胞的病理表型。
Tissue Eng Part A. 2018 Mar;24(5-6):382-393. doi: 10.1089/ten.TEA.2016.0550. Epub 2017 Jul 3.
6
Adipose-derived mesenchymal stem cells suppress fibroblast proliferation of hypertrophic scar through CCL5 and CXCL12.脂肪来源的间充质干细胞通过 CCL5 和 CXCL12 抑制增生性瘢痕成纤维细胞增殖。
Arch Dermatol Res. 2024 Aug 17;316(8):527. doi: 10.1007/s00403-024-03289-2.
7
Wnt4 negatively regulates the TGF-β1-induced human dermal fibroblast-to-myofibroblast transition via targeting Smad3 and ERK.Wnt4 通过靶向 Smad3 和 ERK 负调控 TGF-β1 诱导的人真皮成纤维细胞向肌成纤维细胞转化。
Cell Tissue Res. 2020 Mar;379(3):537-548. doi: 10.1007/s00441-019-03110-x. Epub 2019 Nov 27.
8
Stem Cell-Mediated Paracrine Signaling Alters Fibroplasia in Human Vocal Fold Fibroblasts in Vitro.干细胞介导的旁分泌信号改变体外培养的人声带成纤维细胞的纤维化过程。
Ann Otol Rhinol Laryngol. 2017 Aug;126(8):581-588. doi: 10.1177/0003489417716186. Epub 2017 Jun 21.
9
Inhibitory effect of TGF-β peptide antagonist on the fibrotic phenotype of human hypertrophic scar fibroblasts.转化生长因子-β肽拮抗剂对人增生性瘢痕成纤维细胞纤维化表型的抑制作用
Pharm Biol. 2016 Jul;54(7):1189-97. doi: 10.3109/13880209.2015.1059862. Epub 2015 Jul 2.
10
Bone marrow concentrate-induced mesenchymal stem cell conditioned medium facilitates wound healing and prevents hypertrophic scar formation in a rabbit ear model.骨髓浓缩物诱导间充质干细胞条件培养基促进兔耳模型创面愈合，防止增生性瘢痕形成。
Stem Cell Res Ther. 2019 Aug 28;10(1):275. doi: 10.1186/s13287-019-1383-x.

引用本文的文献

1
Light Exposure as a Tool to Enhance the Regenerative Potential of Adipose-Derived Mesenchymal Stem/Stromal Cells.光暴露作为增强脂肪来源间充质干/基质细胞再生潜能的工具
Cells. 2025 Jul 24;14(15):1143. doi: 10.3390/cells14151143.
2
Photobiomodulation therapy in keloid management: a comprehensive review.瘢痕疙瘩治疗中的光生物调节疗法：一项综述
Front Med (Lausanne). 2025 Jul 9;12:1550662. doi: 10.3389/fmed.2025.1550662. eCollection 2025.
3
Personalized human umbilical cord mesenchymal stem cell-derived exosome pre-treatment based on the simulation of scar microenvironment characteristics: a promising approach for early scar treatment.

本文引用的文献

1
Notch signaling mediated by TGF-β/Smad pathway in concanavalin A-induced liver fibrosis in rats.转化生长因子-β/ Smad信号通路介导的Notch信号在伴刀豆球蛋白A诱导的大鼠肝纤维化中的作用
World J Gastroenterol. 2017 Apr 7;23(13):2330-2336. doi: 10.3748/wjg.v23.i13.2330.
2
Mesenchymal Stem Cells from Adipose Tissue in Clinical Applications for Dermatological Indications and Skin Aging.用于皮肤病学适应症和皮肤衰老临床应用的脂肪组织间充质干细胞
Int J Mol Sci. 2017 Jan 20;18(1):208. doi: 10.3390/ijms18010208.
3
Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways.
基于瘢痕微环境特征模拟的个性化人脐带间充质干细胞衍生外泌体预处理：一种早期瘢痕治疗的有前景的方法。
Mol Biol Rep. 2025 Jul 23;52(1):747. doi: 10.1007/s11033-025-10794-8.
4
Adipose-Derived Stem Cell Products and Combination Therapies for the Treatment of Pathological Scars: A Review of Current Preclinical and Clinical Studies.脂肪源性干细胞产品及联合疗法治疗病理性瘢痕：当前临床前和临床研究综述
Clin Cosmet Investig Dermatol. 2025 May 27;18:1309-1337. doi: 10.2147/CCID.S511067. eCollection 2025.
5
Light assisted modulation of stem cell function and secretome production: a systematic review on current status and new avenues for regenerative medicine.光辅助调节干细胞功能及分泌组生成：关于再生医学现状与新途径的系统综述
Lasers Med Sci. 2025 Feb 12;40(1):83. doi: 10.1007/s10103-025-04339-5.
6
Analysis of long noncoding gene expression and its interactions with protein-coding genes in vascular endothelial cells in keloids.瘢痕疙瘩中血管内皮细胞长链非编码基因表达及其与蛋白质编码基因相互作用的分析。
Eur J Med Res. 2025 Feb 7;30(1):86. doi: 10.1186/s40001-025-02271-6.
7
Inhibition of Small Extracellular Vesicles by GW4869 Does not Disrupt the Paracrine Regulation of Adipose-Derived Mesenchymal Stem Cells Over Keloid Fibroblasts.GW4869对小细胞外囊泡的抑制作用不会破坏脂肪来源间充质干细胞对瘢痕疙瘩成纤维细胞的旁分泌调节。
Aesthetic Plast Surg. 2025 Feb;49(3):917-928. doi: 10.1007/s00266-024-04477-1. Epub 2024 Nov 4.
8
The Role of Extracorporeal Shock Wave Therapy in Keloids and Hypertrophic Scars: A Systematic Review.体外冲击波疗法在瘢痕疙瘩和增生性瘢痕中的作用：一项系统评价
Cureus. 2024 Oct 19;16(10):e71869. doi: 10.7759/cureus.71869. eCollection 2024 Oct.
9
Phenotypic Transitions the Processes Involved in Regulation of Growth and Proangiogenic Properties of Stem Cells, Cancer Stem Cells and Circulating Tumor Cells.表型转化：调节干细胞、癌症干细胞和循环肿瘤细胞的生长和促血管生成特性的过程。
Stem Cell Rev Rep. 2024 May;20(4):967-979. doi: 10.1007/s12015-024-10691-w. Epub 2024 Feb 19.
10
CO Laser for Esthetic Healing of Injuries and Surgical Wounds with Small Parenchymal Defects in Oral Soft Tissues.二氧化碳激光用于口腔软组织实质小缺损损伤及手术伤口的美学修复。
Diseases. 2023 Nov 28;11(4):172. doi: 10.3390/diseases11040172.
转化生长因子-β/ Smad信号通路与其他信号通路之间的信号串扰
Cold Spring Harb Perspect Biol. 2017 Jan 3;9(1):a022137. doi: 10.1101/cshperspect.a022137.
4
CO laser increases the regenerative capacity of human adipose-derived stem cells by a mechanism involving the redox state and enhanced secretion of pro-angiogenic molecules.二氧化碳激光通过涉及氧化还原状态和促血管生成分子分泌增强的机制，提高人脂肪来源干细胞的再生能力。
Lasers Med Sci. 2017 Jan;32(1):117-127. doi: 10.1007/s10103-016-2093-6. Epub 2016 Oct 20.
5
Photobiomodulation of human adipose-derived stem cells using 810nm and 980nm lasers operates via different mechanisms of action.810nm 和 980nm 激光的光生物调节作用通过不同的作用机制对人脂肪来源干细胞起作用。
Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):441-449. doi: 10.1016/j.bbagen.2016.10.008. Epub 2016 Oct 15.
6
Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-β1.瘢痕疙瘩中部分上皮-间充质转化：转化生长因子-β1对瘢痕疙瘩角质形成细胞基因表达的调控。
Burns Trauma. 2016 Aug 23;4(1):30. doi: 10.1186/s41038-016-0055-7. eCollection 2016.
7
Keloids and Hypertrophic Scars: Pathophysiology, Classification, and Treatment.瘢痕疙瘩与增生性瘢痕：病理生理学、分类及治疗
Dermatol Surg. 2017 Jan;43 Suppl 1:S3-S18. doi: 10.1097/DSS.0000000000000819.
8
Notch and TGFβ form a positive regulatory loop and regulate EMT in epithelial ovarian cancer cells.Notch和转化生长因子β（TGFβ）形成一个正调控环路，并在上皮性卵巢癌细胞中调节上皮-间质转化（EMT）。
Cell Signal. 2016 Aug;28(8):838-49. doi: 10.1016/j.cellsig.2016.03.016. Epub 2016 Apr 10.
9
Differentiation Potential of Adipose-Derived Stem Cells When Cocultured with Smooth Muscle Cells, and the Role of Low-Intensity Laser Irradiation.脂肪来源干细胞与平滑肌细胞共培养时的分化潜能及低强度激光照射的作用
Photomed Laser Surg. 2016 Nov;34(11):509-515. doi: 10.1089/pho.2015.3978. Epub 2015 Nov 23.
10
Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications.皮肤再生、伤口愈合中的干细胞及其临床应用。
Int J Mol Sci. 2015 Oct 23;16(10):25476-501. doi: 10.3390/ijms161025476.