Ojeh Nkemcho, Pastar Irena, Tomic-Canic Marjana, Stojadinovic Olivera
Faculty of Medical Sciences, the University of the West Indies, Cave Hill Campus, P.O. Box 64, Bridgetown BB 11000, St. Michael, Barbados.
Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller Medical School, 1600 NW 10th Avenue, RMSB, Room 2023-A, Miami, FL 33136, USA.
Int J Mol Sci. 2015 Oct 23;16(10):25476-501. doi: 10.3390/ijms161025476.
The skin is the largest organ of the body and has an array of functions. Skin compartments, epidermis, and hair follicles house stem cells that are indispensable for skin homeostasis and regeneration. These stem cells also contribute to wound repair, resulting in restoration of tissue integrity and function of damaged tissue. Unsuccessful wound healing processes often lead to non-healing wounds. Chronic wounds are caused by depletion of stem cells and a variety of other cellular and molecular mechanisms, many of which are still poorly understood. Current chronic wound therapies are limited, so the search to develop better therapeutic strategies is ongoing. Adult stem cells are gaining recognition as potential candidates for numerous skin pathologies. In this review, we will discuss epidermal and other stem cells present in the skin, and highlight some of the therapeutic applications of epidermal stem cells and other adult stem cells as tools for cell/scaffold-based therapies for non-healing wounds and other skin disorders. We will also discuss emerging concepts and offer some perspectives on how skin tissue-engineered products can be optimized to provide efficacious therapy in cutaneous repair and regeneration.
皮肤是人体最大的器官，具有一系列功能。皮肤分区、表皮和毛囊中存在干细胞，这些干细胞对于皮肤的稳态和再生不可或缺。这些干细胞也有助于伤口修复，从而恢复受损组织的完整性和功能。伤口愈合过程不成功往往会导致伤口不愈合。慢性伤口是由干细胞耗竭以及多种其他细胞和分子机制引起的，其中许多机制仍知之甚少。目前慢性伤口的治疗方法有限，因此人们正在不断探索开发更好的治疗策略。成体干细胞作为众多皮肤疾病的潜在候选者正逐渐获得认可。在这篇综述中，我们将讨论皮肤中存在的表皮干细胞和其他干细胞，并强调表皮干细胞和其他成体干细胞作为基于细胞/支架疗法治疗不愈合伤口和其他皮肤疾病的工具的一些治疗应用。我们还将讨论新出现的概念，并就如何优化皮肤组织工程产品以在皮肤修复和再生中提供有效的治疗提出一些观点。
