Kotsi Evangelia, Kotsi Elisavet, Perrea Despina N
Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University of Athens, Athens, Greece.
Atten Defic Hyperact Disord. 2019 Sep;11(3):221-232. doi: 10.1007/s12402-018-0276-7. Epub 2018 Oct 26.
The aim of this article was to assess the differences in serum 25(OH)D levels between children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy controls. We used the PubMed (1966-2017), Scopus (2004-2017), ClinicalTrials.gov (2008-2017), Cochrane Central Register of Controlled Trials CENTRAL (2000-2017), and Google Scholar (2004-2017) databases. Statistical meta-analysis was performed with RevMan 5.3. Εight studies were finally included in the present meta-analysis with a total number of 11,324 children. Among them, 2655 were diagnosed with ADHD, while the remaining 8669 were recruited as healthy controls. All eight trials reported significantly lower serum concentrations of 25(OH)D in patients diagnosed with ADHD compared to healthy controls. The pooled data showed that there was a significant difference between the ADHD group and the control group (SMD = - 0.73, 95% CI [- 1.00, - 0.46]). The systematic review and meta-analysis of observational studies demonstrated an inverse association between serum 25(OH)D and young patients with ADHD. Large cohort studies are required to investigate whether vitamin D-deficient infants are more likely to develop ADHD in the future. Also, whether children with ADHD should be supplemented with higher doses of vitamin D3 remains to be confirmed through long-term controlled clinical trials.
本文旨在评估注意力缺陷多动障碍（ADHD）儿童和青少年与健康对照者血清25(OH)D水平的差异。我们使用了PubMed（1966 - 2017年）、Scopus（2004 - 2017年）、ClinicalTrials.gov（2008 - 2017年）、Cochrane对照试验中央注册库CENTRAL（2000 - 2017年）以及谷歌学术（2004 - 2017年）数据库。使用RevMan 5.3进行统计元分析。本元分析最终纳入八项研究，共计11324名儿童。其中，2655名被诊断为ADHD，其余8669名被招募为健康对照者。所有八项试验均报告，与健康对照者相比，被诊断为ADHD的患者血清25(OH)D浓度显著更低。汇总数据显示，ADHD组与对照组之间存在显著差异（标准化均数差 = -0.73，95%置信区间[-1.00, -0.46]）。观察性研究的系统评价和元分析表明，血清25(OH)D与ADHD年轻患者之间存在负相关。需要进行大型队列研究，以调查维生素D缺乏的婴儿未来是否更易患ADHD。此外，ADHD儿童是否应补充更高剂量的维生素D3仍有待通过长期对照临床试验来证实。
