Department of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China.
Small. 2018 Dec;14(49):e1803266. doi: 10.1002/smll.201803266. Epub 2018 Oct 17.
Current technologies for managing acute and chronic pain have focused on reducing the time required for achieving high therapeutic efficiency. Herein a wearable transdermal patch is introduced, employing an acoustic droplet vaporization (ADV) methodology, as an effective noninvasive transdermal platform, for a fast local delivery of the anesthetic agent lidocaine. The skin-worn patch consists of a flexible drug reservoir containing hundreds of micropores loaded with lidocaine, and mixed with the perfluorocarbon (PFC) emulsion. The ultrasound-triggered vaporization of the PFC emulsion provides the necessary force to breach dermal barriers. The drug release kinetics of our model was investigated by measuring the amount of lidocaine that passed through phantom tissue and pigskin barriers. The ADV platform increases the payload skin penetration resulting in shorter treatment times compared to passive diffusion or ultrasound alone, holding considerable promise for addressing the delayed therapeutic action and slow pain relief of existing delivery protocols. It is envisioned that the integration of ADV-based transdermal devices could be expanded to the depth-dependent delivery of other pain management, vaccines, and gene therapy modalities.
目前用于管理急性和慢性疼痛的技术主要集中在减少达到高治疗效率所需的时间上。在此，我们引入了一种可穿戴的透皮贴片，该贴片采用声致液滴汽化（ADV）方法，作为一种有效的非侵入性透皮平台，可快速局部递送麻醉剂利多卡因。这种贴在皮肤上的贴片由一个含有数百个微孔的柔性药物储库组成，微孔中装载有混合了全氟碳（PFC）乳液的利多卡因。PFC 乳液的超声触发汽化提供了突破皮肤屏障所需的力。通过测量穿过虚拟组织和猪皮屏障的利多卡因量，研究了我们模型的药物释放动力学。与被动扩散或单独使用超声波相比，ADV 平台增加了药物的皮肤穿透载药量，从而缩短了治疗时间，为解决现有给药方案治疗效果延迟和疼痛缓解缓慢的问题带来了很大的希望。可以预见，基于 ADV 的透皮设备的整合可以扩展到其他疼痛管理、疫苗和基因治疗方式的深度依赖性递送上。
