Department of Intelligent Systems Engineering, Indiana University, Bloomington, IN, 47405, USA.
Biopharmaceutical Research Institute, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Nat Commun. 2023 Feb 16;14(1):869. doi: 10.1038/s41467-023-36581-2.
Transdermal drug delivery provides convenient and pain-free self-administration for personalized therapy. However, challenges remain in treating acute diseases mainly due to their inability to timely administrate therapeutics and precisely regulate pharmacokinetics within a short time window. Here we report the development of active acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand acute disease management. Through the integration of active acoustic metamaterials, a compact therapeutic patch is integrated for penetration of skin stratum corneum and active percutaneous transport of therapeutics with precise control of dose and rate over time. Moreover, the patch device quantitatively regulates the dosage and release kinetics of therapeutics and achieves better delivery performance in vivo than through subcutaneous injection. As a proof-of-concept application, we show our method can reverse life-threatening acute allergic reactions in a female mouse model of anaphylaxis via a multi-burst delivery of epinephrine, showing better efficacy than a fixed dosage injection of epinephrine, which is the current gold standard 'self-injectable epinephrine' strategy. This innovative method may provide a promising means to manage acute disease for personalized medicine.
透皮给药为个性化治疗提供了方便、无痛的自我给药方式。然而，在治疗急性疾病方面仍然存在挑战，主要是因为它们无法及时给药，并且无法在短时间窗口内精确调节药代动力学。在这里，我们报告了主动声超材料驱动的透皮药物输送的发展，用于快速和按需急性疾病管理。通过主动声超材料的集成，一个紧凑的治疗贴片被集成用于穿透皮肤角质层和主动经皮输送药物，同时可以精确控制剂量和时间上的速率。此外，该贴片装置定量调节药物的剂量和释放动力学，并且在体内的输送性能优于皮下注射。作为概念验证应用，我们通过多脉冲肾上腺素传递显示，我们的方法可以逆转过敏反应雌性小鼠模型中的危及生命的急性过敏反应，其疗效优于肾上腺素的固定剂量注射，后者是目前的黄金标准“自我注射肾上腺素”策略。这种创新方法可能为个性化医学提供一种有前途的急性疾病管理手段。
