1 Park Nicollet Clinic & HealthPartners Institute Minneapolis MN.
2 University of Minnesota Minneapolis MN.
J Am Heart Assoc. 2018 Aug 21;7(16):e009172. doi: 10.1161/JAHA.118.009172.
Background Visceral adipose tissue ( VAT ) and other measures of central obesity predict incident atherosclerotic cardiovascular disease ( ASCVD ) events in middle-aged individuals, but these associations are less certain in older individuals age 70 years and older. Our objective was to estimate the associations of VAT and the android-gynoid fat mass ratio, another measure of central obesity, with incident ASCVD events among a large cohort of older men. Methods and Results Two thousand eight hundred ninety-nine men (mean [ SD ] age 76.3 [5.5] years) enrolled in the Outcomes of Sleep Disorders in Older Men study had rigorous adjudication of incident ASCVD events (myocardial infarction, coronary heart disease death, or fatal or nonfatal stroke). We used proportional hazards models to estimate the hazard ratios for incident ASCVD per SD increase of VAT or android-gynoid fat mass ratio (measured at baseline with dual-energy absorptiometry), adjusted for age, race, education, systolic blood pressure, smoking status, oxidized low-density lipoprotein level, treatment for hypertension, statin use, aspirin use, presence of diabetes mellitus, and study enrollment site. Over a mean ( SD ) follow-up period of 7.9 (3.4) years, 424 men (14.6%) had an incident ASCVD event. Neither VAT nor android-gynoid fat mass ratio were associated with incident ASCVD events, either unadjusted or after multivariable-adjustment (hazard ratios [95% confidence interval ] per SD increase 1.02 [0.92-1.13] and 1.05 [0.95-1.17], respectively). Conclusions Central adipose tissue, as measured by VAT or android-gynoid fat mass ratio, was not associated with incident ASCVD events in this study of older men.
内脏脂肪组织（VAT）和其他中心性肥胖指标可预测中年个体发生动脉粥样硬化性心血管疾病（ASCVD）事件，但这些关联在年龄 70 岁及以上的老年人中不太确定。我们的目的是评估 VAT 和另一种中心性肥胖指标——腹型/臀型脂肪质量比与老年男性大型队列中 ASCVD 事件的相关性。
2899 名男性（平均[标准差]年龄 76.3[5.5]岁）参加了老年男性睡眠障碍研究，这些男性接受了 ASCVD 事件（心肌梗死、冠心病死亡或致死性或非致死性卒中）的严格审查。我们使用比例风险模型，根据年龄、种族、教育程度、收缩压、吸烟状况、氧化型低密度脂蛋白水平、高血压治疗、他汀类药物使用、阿司匹林使用、糖尿病的存在以及研究入组地点，对每增加一个标准差的 VAT 或腹型/臀型脂肪质量比（在基线时用双能吸收仪测量）与 ASCVD 事件的风险比进行估计。平均（标准差）随访 7.9（3.4）年后，424 名男性（14.6%）发生了 ASCVD 事件。无论是未校正还是校正后多变量分析，VAT 或腹型/臀型脂肪质量比均与 ASCVD 事件无关（每增加一个标准差的风险比分别为 1.02[0.92-1.13]和 1.05[0.95-1.17]）。
在这项对老年男性的研究中，VAT 或腹型/臀型脂肪质量比所测量的中心性脂肪组织与 ASCVD 事件无关。
