Zhang Wenhao, Su Xiaoyu, Liu SiHua, Yue Tong, Tu Zhixin, Zhang Hongqiang, Li Chenghua, Yao Haifeng, Wang Jumei, Zheng Xueying, Luo Sihui, Ding Yu
Division of Life Sciences and Medicine, Department of Endocrinology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, 230001, China.
Graduate School, Bengbu Medical College, Bengbu, Anhui, China.
Acta Diabetol. 2025 Jan 10. doi: 10.1007/s00592-025-02447-w.
Visceral adipose tissue (VAT) is known to play a role in the development of metabolic and cardiovascular disease (CVD). However, the age- and sex-specific associations between VAT and these diseases remain unclear.
In this cross-sectional study, 1,150 participants (39.5% women; mean age 61.5 years) underwent VAT measurement using dual abdominal bioelectrical impedance analysis (BIA). The four age groups that the participants were divided into were 18-44, 45-59, 60-74, and ≥ 75 years. The relationships between VAT and cardiometabolic outcomes were analyzed by age and sex using multivariable logistic regression.
Significant associations between VAT and metabolic health status were observed in middle-aged (45-59 years; OR = 1.41, 95% CI: 1.04-1.92) and elderly adults (60-74 years; OR = 1.45, 95% CI: 1.10-1.92). VAT demonstrated age-dependent relationships with cardiovascular risk factors, with the strongest associations found in the 60-74 years group for hypertension (OR: 1.55, 95% CI: 1.22-1.98) and low high-density lipoprotein cholesterol (OR: 1.66, 95% CI: 1.33-2.08). Notably, the VAT-CVD association was most pronounced in elderly women (60-74 years; OR: 1.86, 95% CI: 1.14-3.11), while no significant associations were observed in men across all age groups.
The impact of VAT on metabolic and cardiovascular disease risk varies by age and sex, with particularly strong associations observed in elderly women. This highlights the need for tailored prevention and treatment strategies.
已知内脏脂肪组织（VAT）在代谢和心血管疾病（CVD）的发生发展中起作用。然而，VAT与这些疾病之间的年龄和性别特异性关联仍不清楚。
在这项横断面研究中，1150名参与者（39.5%为女性；平均年龄61.5岁）使用双腹部生物电阻抗分析（BIA）进行VAT测量。参与者被分为四个年龄组：18 - 44岁、45 - 59岁、60 - 74岁和≥75岁。使用多变量逻辑回归按年龄和性别分析VAT与心脏代谢结局之间的关系。
在中年（45 - 59岁；OR = 1.41，95%CI：1.04 - 1.92）和老年人（60 - 74岁；OR = 1.45，95%CI：1.10 - 1.92）中观察到VAT与代谢健康状况之间存在显著关联。VAT与心血管危险因素呈年龄依赖性关系，在60 - 74岁组中高血压（OR：1.55，95%CI：1.22 - 1.98）和低高密度脂蛋白胆固醇（OR：1.66，95%CI：1.33 - 2.08）的关联最强。值得注意的是，VAT与CVD的关联在老年女性（60 - 74岁；OR：1.86，95%CI：1.14 - 3.11）中最为明显，而在所有年龄组的男性中未观察到显著关联。
VAT对代谢和心血管疾病风险的影响因年龄和性别而异，在老年女性中观察到的关联尤为强烈。这突出了制定针对性预防和治疗策略的必要性。
