Department of Gastroenterology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Front Endocrinol (Lausanne). 2024 Jan 8;14:1296398. doi: 10.3389/fendo.2023.1296398. eCollection 2023.
The Visceral Adiposity Index (VAI) is a straightforward and gender-specific marker that combines anthropometric measurements with lipid profiles. The objective of this study was to evaluate the relationship between VAI and coronary heart disease (CHD).
The study examined data collected from adults during the NHANES 1999-2018 cycle. The analyses were weighted, and multivariable logistic regression models were employed to investigate the association between VAI and CHD. Additionally, subgroup analyses stratified by age were conducted. To evaluate the impact of VAI levels on survival outcomes, the study utilized the Kaplan-Meier method and performed the log-rank test to evaluate the survival outcome of participants with different VAI levels. The study findings revealed a significant association between VAI and CHD, indicating a non-linear relationship where an increase in VAI was associated with an elevated risk of CHD. High levels of VAI were linked to an increased prevalence of CHD (Q4 vs Q1, OR 1.50, 95% CI 1.12-2.01, P=0.01). Additionally, higher levels of VAI were associated with a poorer overall prognosis in terms of survival outcomes. There were no statistically significant differences in survival outcomes among the population with CHD.
The results of this study highlighted a significant association between VAI and CHD, with a non-linear relationship observed. High VAI levels were associated with an increased risk of CHD and poor survival outcomes, emphasizing the importance of understanding and managing this risk factor, particularly in older age groups.
内脏脂肪指数（VAI）是一种简单且具有性别特异性的标志物，它将人体测量学指标与脂质谱相结合。本研究旨在评估 VAI 与冠心病（CHD）之间的关系。
本研究分析了 1999-2018 年 NHANES 周期中成年人的数据。采用加权分析，并采用多变量逻辑回归模型探讨 VAI 与 CHD 之间的关系。此外，还按年龄进行了亚组分析。为了评估 VAI 水平对生存结局的影响，本研究采用 Kaplan-Meier 方法和对数秩检验评估不同 VAI 水平参与者的生存结局。研究结果表明 VAI 与 CHD 之间存在显著关联，表明 VAI 增加与 CHD 风险升高之间存在非线性关系。高 VAI 水平与 CHD 的患病率增加相关（Q4 与 Q1 相比，OR 为 1.50，95%CI 为 1.12-2.01，P=0.01）。此外，VAI 水平较高与生存结局较差相关。CHD 人群的生存结局无统计学差异。
本研究结果强调了 VAI 与 CHD 之间存在显著关联，且呈非线性关系。高 VAI 水平与 CHD 风险增加和生存结局较差相关，强调了理解和管理这一风险因素的重要性，特别是在老年人群中。
