Department of Medical IT Engineering, Soonchunhyang University, College of Medical Sciences, Asan, Korea.
Institute of Occupational and Environmental Medicine, Soonchunhyang University, Asan, Korea.
J Korean Med Sci. 2018 Oct 1;33(44):e278. doi: 10.3346/jkms.2018.33.e278. eCollection 2018 Oct 29.
We evaluated the association of blood pressure (BP) with blood levels of cadmium, lead, and cadmium and lead together (cadmium + lead) in a representative sample of adolescents from Korea.
We used 2010-2016 data from the Korean National Health and Nutrition Examination Survey. This cross-sectional study enrolled adolescents aged at 10-18 years-old who completed a health examination survey and had blood measurements of lead and cadmium. The association of adjusted mean differences in diastolic and systolic BP with doubling of blood lead and cadmium were estimated by regression of BP against log-transformed blood metals and their quartiles after covariate adjustment. Adjusted odds ratio for prehypertension were calculated for log-transformed blood levels of lead and cadmium and their quartiles.
Our analysis of adolescents in Korea indicated that blood levels of lead and cadmium were not significantly associated with increased BP or risk of prehypertension. However, the cadmium + lead level was associated with prehypertension. Previous studies showed that blood levels of lead and cadmium were associated with increased BP and risk of hypertension in adult populations. We found no such association in Korean adolescents.
We found that the cadmium + lead level was associated with prehypertension. The differences between adults and adolescents are because adolescents generally have lower levels of these blood metals or because adolescents only rarely have hypertension.
我们评估了血压（BP）与血镉、血铅和镉铅联合水平（镉+铅）在韩国代表性青少年样本中的相关性。
我们使用了 2010-2016 年韩国国家健康和营养调查的数据。这项横断面研究纳入了完成健康检查调查且血铅和镉检测值可用的 10-18 岁青少年。在调整协变量后，采用 BP 对血金属及其四分位距的对数转换值进行回归，估计 BP 与血铅和镉倍增的校正均数差值之间的关联。计算血铅和镉及其四分位距的对数转换值与高血压前期的比值比。
我们对韩国青少年的分析表明，血铅和镉水平与 BP 升高或高血压前期风险增加无关。然而，镉+铅水平与高血压前期相关。既往研究表明，血铅和镉水平与成人人群 BP 升高和高血压风险增加相关。我们在韩国青少年中未发现这种关联。
我们发现镉+铅水平与高血压前期相关。成年人和青少年之间的差异可能是因为青少年的这些血金属水平通常较低，或者因为青少年很少发生高血压。
