Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Department of Oncology, Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
J Cell Physiol. 2019 Apr;234(4):3336-3346. doi: 10.1002/jcp.27293. Epub 2018 Oct 30.
The chemokine system is a complex arrangement of molecules that attract leukocytes to the site of injury or inflammation. This chemotactic behavior gives the system the name "Chemokine." The intricate and redundant nature of the chemokine system has made it a subject of ongoing scientific investigation. Obesity is characterized as low-grade systemic or chronic inflammation that is responsible for the release of cytokines, adipokines, and chemokines. Excessive tissue fat expansion triggers the release of chemokines, which in turn attract various leukocytes and activate the resident immune surveillance system, eventually leading to worsening of obesity and other related comorbidities. To date, 50 chemokines and 20 chemokine receptors that belong to the G-protein-coupled receptor family have been discovered, and over the past two decades, the physiological and pathological roles of many of these chemokines and their receptors have been elucidated. The objective of this review is to present an update on the link between chemokines and obesity under the light of recent knowledge.
趋化因子系统是一种复杂的分子排列，吸引白细胞到损伤或炎症部位。这种趋化行为赋予了该系统“趋化因子”的名称。趋化因子系统的复杂和冗余性质使其成为当前科学研究的课题。肥胖的特征是低度全身性或慢性炎症，这是细胞因子、脂肪因子和趋化因子释放的原因。组织脂肪过度扩张会触发趋化因子的释放，进而吸引各种白细胞并激活常驻免疫监视系统，最终导致肥胖恶化和其他相关并发症。迄今为止，已经发现了 50 种趋化因子和 20 种属于 G 蛋白偶联受体家族的趋化因子受体，在过去的二十年中，许多这些趋化因子及其受体的生理和病理作用已经被阐明。本综述的目的是根据最近的知识，介绍趋化因子与肥胖之间的联系的最新进展。
