Johnston J G, Boyd S R, van der Kooy D
Brain Res. 1987 Jun;430(2):310-4. doi: 10.1016/0165-3806(87)90166-0.
In order to assess the intrinsic potential of the isolated embryonic striatum to develop its adult patch and matrix compartments, embryonic day 16 striata were transplanted into the anterior eye chamber of adult host rats. After 2-12 weeks of survival the transplants showed heterogeneous and in the majority of cases complementary distributions of opiate receptor binding and acetylcholinesterase staining, which mark the patch and matrix compartments of the adult striatum, respectively. The complementarity of patch and matrix markers in the transplants shows that the transplants do compartmentalize. However, the density of the markers in the transplants did not reach the levels seen in the adult striatum. The results suggest that the commitment of cells to a striatal compartment is a very early event in the embryonic development of the forebrain.
为了评估分离的胚胎纹状体发育其成年期斑块和基质区室的内在潜力，将胚胎第16天的纹状体移植到成年宿主大鼠的前房。存活2至12周后，移植物显示出阿片受体结合和乙酰胆碱酯酶染色的异质性分布，且在大多数情况下是互补分布，这两种分布分别标记成年纹状体的斑块和基质区室。移植物中斑块和基质标记物的互补性表明移植物确实进行了区室化。然而，移植物中标记物的密度未达到成年纹状体中的水平。结果表明，细胞向纹状体区室的定向分化是前脑胚胎发育中非常早期的事件。
