van der Kooy D, Fishell G
Brain Res. 1987 Jan 13;401(1):155-61. doi: 10.1016/0006-8993(87)91176-0.
The striatum of the mammalian forebrain is composed of two complementary functional compartments, the patches and the matrix. By injecting [3H]thymidine at different embryonic times and sacrificing the rats as young adults, we found that the earliest neurons to leave the mitotic cycle were restricted to the patch compartment. Neurons that became postmitotic at later times preferentially joined the matrix compartment. Distinctive periods of cell proliferation may underlie pattern formation throughout the developing forebrain.
哺乳动物前脑的纹状体由两个互补的功能区组成，即斑块区和基质区。通过在不同胚胎时期注射[3H]胸腺嘧啶核苷，并在大鼠成年早期将其处死，我们发现最早离开有丝分裂周期的神经元局限于斑块区。在较晚时期进入有丝分裂后阶段的神经元则优先加入基质区。细胞增殖的不同时期可能是整个发育中的前脑模式形成的基础。
