类风湿关节炎真的会在妊娠期间缓解吗？一项系统评价和荟萃分析。
Does Rheumatoid Arthritis Really Improve During Pregnancy? A Systematic Review and Metaanalysis.
机构信息
From the Rheumatology Department, London North West Healthcare National Health Service (NHS) Trust; General Medicine, Croydon University Hospital; Statistics Department, Royal Free Hospital; Centre for Rheumatology Research, Rayne Institute, University College London, London, UK.
H. Jethwa, Specialist Registrar in Rheumatology, BSc, MBChB, MRCP, Rheumatology Department, London North West Healthcare NHS Trust; S. Lam, General Practitioner Trainee, BSc, MBBS, General Medicine, Croydon University Hospital; C. Smith, Research Statistician, PhD, Statistics Department, Royal Free Hospital; I. Giles, Consultant Rheumatologist, PhD, FRCP, Centre for Rheumatology Research, Rayne Institute, University College London.
出版信息
J Rheumatol. 2019 Mar;46(3):245-250. doi: 10.3899/jrheum.180226. Epub 2018 Nov 1.
OBJECTIVE
We performed a systematic review and metaanalysis to assess rheumatoid arthritis (RA) disease activity during pregnancy using objective disease activity scoring systems.
METHODS
A systematic review of PubMed, EMBASE/Medline, Cochrane, and LactMed databases was performed. Our inclusion criteria for analysis were prospective studies, more than 5 patients per study, and data on RA using an objective scoring system conducted by a clinician/health professional.
RESULTS
Ten studies were eligible for final analysis, which included 237 patients, of which prepartum data were available for 204 patients. Postpartum disease activity was recorded in 135 pregnancies.
CONCLUSION
Disease activity improved in 60% of patients with RA in pregnancy and flared in 46.7% postpartum.
目的
我们进行了系统评价和荟萃分析，使用客观疾病活动评分系统评估妊娠期间类风湿关节炎（RA）的疾病活动度。
方法
对 PubMed、EMBASE/Medline、Cochrane 和 LactMed 数据库进行了系统检索。我们的分析纳入标准为前瞻性研究、每例研究患者数超过 5 例、以及由临床医生/卫生专业人员使用客观评分系统对 RA 进行的数据。
结果
10 项研究符合最终分析的条件，共纳入 237 例患者，其中 204 例患者有产前数据。135 例妊娠中记录了产后疾病活动度。
结论
60%的妊娠 RA 患者的疾病活动度改善，46.7%的患者产后病情加重。
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