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苔藓样谱系的多种临床表现:一例患有额部纤维性秃发、色素性扁平苔藓和甲扁平苔藓的患者。

Multiple Clinical Manifestations of Lichenoid Spectrum: A Patient with Frontal Fibrosing Alopecia, Lichen Planus Pigmentosus, and Nail Lichen Planus.

作者信息

Sarikaya Solak Sezgi, Sezer Burak Emre, Anzerlioglu Mete, Tokmak Zeynep, Topuz Canberk

机构信息

Department of Dermatology, Faculty of Medicine, Trakya University, Edirne, Turkey.

Faculty of Medicine, Trakya University, Edirne, Turkey.

出版信息

Skin Appendage Disord. 2022 Jul;8(4):333-337. doi: 10.1159/000521715. Epub 2022 Jan 28.

Abstract

INTRODUCTION

Frontal fibrosing alopecia (FFA) is characterized by irreversible, symmetrical band-like hair loss in the frontotemporal region. Lichen planus pigmentosus (LPP) is a variant of lichen planus (LP) that presents with hyperpigmented macules and patches predominantly in sun-exposed areas. Nail LP is a subtype of LP that can be present alone or with other forms of LP.

CASE REPORT

We report a rare case of a 59-year-old woman presenting with symmetrical, gray-brown, hyperpigmented lesions on her neck and face, band-like alopecia in the frontotemporal region, severe onycholysis in two fingernails, and prominent longitudinal ridging in all fingernails. Clinical, dermoscopic, and histological findings established a diagnosis of FFA associated with LPP and nail LP was established.

DISCUSSION/CONCLUSION: In recent years, it has been established that FFA can be associated with LPP and it is thought to be a variant of lichen planopilaris. Nail involvement is rarely reported in FFA or LPP. To our knowledge, the presence of the three conditions in the same patient has not been previously reported. Although rare we would like to emphasize the importance of a careful examination of the nails in patients with FFA and/or LPP to prevent irreversible nail changes.

摘要

引言

额部纤维性秃发(FFA)的特征是额颞部出现不可逆的对称性带状脱发。色素性扁平苔藓(LPP)是扁平苔藓(LP)的一种变体,主要表现为暴露于阳光下部位的色素沉着斑和斑片。甲扁平苔藓是扁平苔藓的一种亚型,可单独出现或与其他形式的扁平苔藓同时出现。

病例报告

我们报告了一例罕见病例,一名59岁女性,其颈部和面部出现对称性灰棕色色素沉着病变,额颞部带状脱发,两个手指甲严重甲分离,所有手指甲均有明显的纵嵴。临床、皮肤镜和组织学检查结果确诊为与LPP相关的FFA,并确诊为甲扁平苔藓。

讨论/结论:近年来,已证实FFA可与LPP相关,并且被认为是扁平苔藓性毛发角化病的一种变体。FFA或LPP累及指甲的情况鲜有报道。据我们所知,同一患者同时出现这三种情况此前尚未见报道。尽管罕见,但我们想强调,对于FFA和/或LPP患者,仔细检查指甲以防止不可逆的指甲改变非常重要。

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本文引用的文献

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Lichen planus pigmentosus and its variants: review and update.色素性扁平苔藓及其变异型:综述与更新。
Int J Dermatol. 2018 May;57(5):505-514. doi: 10.1111/ijd.13806. Epub 2017 Oct 26.
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Coexistence of nail lichen planus and lichen planus pigmentosus.扁平苔藓甲与色素性扁平苔藓共存。
An Bras Dermatol. 2016 Sep-Oct;91(5 suppl 1):20-22. doi: 10.1590/abd1806-4841.20164635.

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