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: The incidences of typhoid and paratyphoid remain high and these diseases still pose a public health problem in China and in Zhejiang Province in particular. This study aimed to investigate the trend of typhoid and paratyphoid in Zhejiang Province from 1953 to 2014 and to provide a theoretical basis for the prevention and control of these diseases. : Included in this study were compiled epidemiological data of typhoid and paratyphoid cases in Zhejiang from 1953 to 2003 and epidemiological data of those from 2004 to 2014 registered in the China Information System for Diseases Control and Prevention. Description methods were employed to explore the epidemiological characteristics, including long-term trend, gender distribution, age distribution, and occupation distribution. Incidence maps were made to represent the annual average incidences for each municipality. Spearman's rank correlation was performed to detect the correlation between incidence and average elevation, and circular distribution was calculated to identify the seasonality and peak days of the diseases. A -value of <0.05 was considered statistically significant. : A total of 182,602 typhoid and paratyphoid cases were reported in Zhejiang Province from 1953 to 2014, and the average annual incidence was 7.89 per 100,000 population. The incidence in 2014 decreased by 93.82% compared with that in 1953 and by 95.00% compared with the highest incidence rate. The average incidence before 2003 was negatively correlated with the average elevation of each region in Zhejiang province ( < 0, < 0.05), but there was no statistically significant correlation from 2003. The peak period of diseases fell in the months from April to October every year. The incidence among the population group aged over 35 rose gradually but declined sharply among those between 20 and 34. : The incidence of typhoid and paratyphoid decreased in Zhejiang Province from 1953 to 2014 but remained high in some regions. Proper measures for prevention and control are warranted in the southeast coast areas and for high-risk populations.

浙江省伤寒副伤寒发病水平仍较高，一直是浙江省重点防治的疾病之一。本研究旨在分析浙江省 1953-2014 年伤寒副伤寒的流行趋势，为防治提供理论依据。

本研究收集了 1953-2003 年浙江省伤寒副伤寒的疫情资料和 2004-2014 年中国疾病预防控制信息系统中登记的疫情资料，采用描述性方法分析其流行特征，包括长期趋势、性别分布、年龄分布和职业分布。绘制发病地图表示各地区的年平均发病率。采用 Spearman 秩相关分析发病率与平均海拔高度的相关性，用圆形分布分析疾病的季节性和高峰日。以 P 值<0.05 为差异有统计学意义。

结果显示，1953-2014 年浙江省共报告伤寒副伤寒 182602 例，年均发病率为 7.89/10 万。2014 年发病率与 1953 年相比下降 93.82%，与最高年份相比下降 95.00%。2003 年前浙江省各地区平均海拔与平均发病率呈负相关（<0，<0.05），2003 年后两者无统计学相关性。疾病的高峰期为每年 4-10 月。35 岁以上人群发病率逐渐上升，20-34 岁人群发病率急剧下降。