Witjaksono Fiastuti, Lukito Widjaja, Wijaya Andi, Annisa Nagita Gianty, Jutamulia Joan, Nurwidya Fariz, Simadibrata Marcellus
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia.
Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON), Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia.
BMC Res Notes. 2018 Nov 3;11(1):787. doi: 10.1186/s13104-018-3895-3.
Gut hormones, such as PYY and ghrelin, are associated with appetite control and obesity. Protein is thought to be the most satiating nutrient and could affect the production of several gut hormones. The purpose of the current study was to find the effect of breakfast with different protein composition on PYY, ghrelin, and ad libitum intake 4 h after breakfast.
This clinical trial involves 22 obese women participants. Subjects were given three types of breakfast: low protein consumption (12.4% protein), medium protein (23.5% protein), and high protein (40.6% protein). PYY and ghrelin levels were measured at 0, 15, 60, 120, and 180 min after breakfast. Ad libitum meal was given 4 h after breakfast and measured after. This study found that there is no significant difference in PYY and ghrelin level at each measurement time between different type of breakfast. This study also found no significant difference of ad libitum energy intake between different type of breakfast. Trial registration ClinicalTrials.gov NCT03697486, 3 December 2018. Retrospectively registered.
肠道激素，如肽YY（PYY）和胃饥饿素，与食欲控制和肥胖有关。蛋白质被认为是最具饱腹感的营养素，并且可能影响多种肠道激素的产生。本研究的目的是探究不同蛋白质组成的早餐对早餐后4小时的PYY、胃饥饿素和随意摄入量的影响。
这项临床试验纳入了22名肥胖女性参与者。受试者被给予三种类型的早餐：低蛋白摄入（12.4%蛋白质）、中等蛋白（23.5%蛋白质）和高蛋白（40.6%蛋白质）。在早餐后0、15、60、120和180分钟测量PYY和胃饥饿素水平。早餐后4小时给予随意餐并在之后进行测量。本研究发现，不同类型早餐在各测量时间点的PYY和胃饥饿素水平无显著差异。本研究还发现不同类型早餐的随意能量摄入量无显著差异。试验注册ClinicalTrials.gov NCT03697486，2018年12月3日。回顾性注册。
