de Boer Esther C, de Rooij Susanne R, Olthof Margreet R, Vrijkotte Tanja G M
Department of Public Health, Academic Medical Centre, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam, The Netherlands; Department of Health Sciences, Faculty of Earth & Life Sciences, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.
Department of Public Health, Academic Medical Centre, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam, The Netherlands; Departments of Clinical Epidemiology, Biostatistics & Bio Informatics, Academic Medical Centre at the University of Amsterdam, Amsterdam, The Netherlands.
Clin Nutr ESPEN. 2018 Dec;28:232-235. doi: 10.1016/j.clnesp.2018.08.020. Epub 2018 Sep 11.
Research in adults shows high intakes of sugar-sweetened beverages (SSBs) increases blood pressure (BP), however evidence in children is scarce and inconclusive. No studies have investigated autonomic nervous system (ANS) activation due to SSBs in children. Our aim was to investigate the associations between SSBs intake, BP and ANS activation in children.
Cross-sectional data collected in 2008-2010 at age 5/6 (n = 2519) and in 2015-2016 at age 11/12 (n = 769) years in the Amsterdam Born Children and their Development-study were analyzed in 2017. Systolic blood pressure (SBP) and diastolic blood pressure (DBP), as well as pre-ejection period (PEP; sympathetic activation) and respiratory sinus arrhythmia (RSA; parasympathetic activation) were measured during supine position. SSBs intake was self-reported.
After adjustments for covariates, including weight status, no associations between SSBs intake, BP and ANS measures were found at age 5/6. At age 11/12, one serving/day increase in SSBs was associated with 0.8 mmHg increase in SBP (95%CI:0.4; 1.2), 0.3 mmHg increase in DBP (0.0; 0.5) and 0.9 msec decrease in PEP (-1.5;-0.2). Children in the highest SSBs tertile had an increase of 2.3 mmHg in SBP (0.7; 4.0) and a decrease of 3.6 msec in PEP (-6.7;-0.6) compared to children in the lowest tertile.
In children aged 11/12, high intake of SSBs was associated with increased BP, which might be due to increased sympathetic nervous system activation. Importantly, these associations were independent of weight status.
针对成年人的研究表明，高糖饮料（SSB）摄入量增加会导致血压升高（BP），然而儿童方面的证据却很少且尚无定论。尚无研究调查过儿童饮用高糖饮料后自主神经系统（ANS）的激活情况。我们的目的是研究儿童高糖饮料摄入量、血压与自主神经系统激活之间的关联。
对2008 - 2010年收集的5/6岁（n = 2519）和2015 - 2016年收集的11/12岁（n = 769）的阿姆斯特丹出生儿童及其发育研究的横断面数据在2017年进行分析。在仰卧位测量收缩压（SBP）和舒张压（DBP），以及射血前期（PEP；交感神经激活）和呼吸性窦性心律不齐（RSA；副交感神经激活）。高糖饮料摄入量通过自我报告获得。
在对包括体重状况在内的协变量进行调整后发现，5/6岁儿童的高糖饮料摄入量、血压与自主神经系统测量指标之间没有关联。在11/12岁儿童中，高糖饮料摄入量每天增加一份与收缩压升高0.8 mmHg（95%CI：0.4；1.2）、舒张压升高0.3 mmHg（0.0；0.5）以及射血前期缩短0.9毫秒（-1.5；-0.2）相关。与处于高糖饮料摄入量最低三分位数的儿童相比，处于最高三分位数的儿童收缩压升高2.3 mmHg（0.7；4.0），射血前期缩短3.6毫秒（-6.7；-0.6）。
在11/12岁儿童中，高糖饮料高摄入量与血压升高有关，这可能是由于交感神经系统激活增加所致。重要的是，这些关联独立于体重状况。
