组抗生素药敏和耐药基因分型的遗传相关性。
Genetic Correlation of Antibiotic Susceptibility and Resistance Genotyping for the Group.
机构信息
Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, MOE Key Laboratory of Major Diseases in Children, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing, China.
出版信息
Antimicrob Agents Chemother. 2018 Dec 21;63(1). doi: 10.1128/AAC.01523-18. Print 2019 Jan.
Abstract
Treatment efficacy of infections depends on bacterial genotype. Here, the relationship between genotype, as determined by sequence analysis, and antibiotic resistance phenotype was analyzed. The results demonstrate that genotype characteristics, including (41) sequevar and mutations of and , are predictive of clarithromycin and amikacin resistance.
摘要
感染的治疗效果取决于细菌基因型。在这里，通过序列分析确定基因型与抗生素耐药表型之间的关系。结果表明，基因型特征，包括（41）序列变异和 及 的突变，可预测克拉霉素和阿米卡星的耐药性。
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本文引用的文献
1
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2
Resazurin Microtiter Assay for Clarithromycin Susceptibility Testing of Clinical Isolates of Mycobacterium abscessus Group.
J Clin Lab Anal. 2016 Sep;30(5):751-5. doi: 10.1002/jcla.21933. Epub 2016 May 12.
3
Standardized interpretation of antibiotic susceptibility testing and resistance genotyping for Mycobacterium abscessus with regard to subspecies and erm41 sequevar.
J Antimicrob Chemother. 2016 Aug;71(8):2208-12. doi: 10.1093/jac/dkw130. Epub 2016 May 4.
4
The drug resistance profile of Mycobacterium abscessus group strains from Korea.
Ann Lab Med. 2014 Jan;34(1):31-7. doi: 10.3343/alm.2014.34.1.31. Epub 2013 Dec 6.
5
Comparison of six simple methods for extracting ribosomal and mitochondrial DNA from Toxocara and Toxascaris nematodes.
Exp Parasitol. 2013 Jun;134(2):155-9. doi: 10.1016/j.exppara.2013.02.008. Epub 2013 Mar 13.
6
Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm(41).
J Antimicrob Chemother. 2012 Nov;67(11):2606-11. doi: 10.1093/jac/dks279. Epub 2012 Jul 24.
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Clin Infect Dis. 2011 Mar 1;52(5):565-71. doi: 10.1093/cid/ciq237.
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10
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