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专科急诊护理与慢性阻塞性肺疾病的治疗结果

Specialist emergency care and COPD outcomes.

作者信息

Lane Nicholas David, Brewin Karen, Hartley Tom Murray, Gray William Keith, Burgess Mark, Steer John, Bourke Stephen C

机构信息

Respiratory Research Division, Research and Development, Northumbria Healthcare NHS Foundation Trust, North Tyneside General Hospital, North Shields, UK.

Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.

出版信息

BMJ Open Respir Res. 2018 Oct 14;5(1):e000334. doi: 10.1136/bmjresp-2018-000334. eCollection 2018.

Abstract

INTRODUCTION

In exacerbation of chronic obstructive pulmonary disease (ECOPD) requiring hospitalisation greater access to respiratory specialists improves outcome, but is not consistently delivered. The UK National Confidential Enquiry into Patient Outcome and Death 2015 enquiry showed over 25% of patients receiving acute non-invasive ventilation (NIV) for ECOPD died in hospital. On 16 June 2015 the Northumbria Specialist Emergency Care Hospital (NSECH) opened, introducing 24/7 specialty consultant on-call, direct admission from the emergency department to specialty wards and 7-day consultant review. A Respiratory Support Unit opened for patients requiring NIV. Before NSECH the NIV service included mandated training and competency assessment, 24/7 single point of access, initiation of ventilation in the emergency department, a door-to-mask time target, early titration of ventilation pressures and structured weaning. Pneumonia or hypercapnic coma complicating ECOPD have never been considered contraindications to NIV. After NSECH staff-patient ratios increased, the NIV pathway was streamlined and structured daily multidisciplinary review introduced. We compared our outcomes with historical and national data.

METHODS

Patients hospitalised with ECOPD between 1 January 2013 and 31 December 2016 were identified from coding, with ventilation status and radiological consolidation confirmed from records. Age, gender, admission from nursing home, consolidation, revised Charlson Index, key comorbidities, length of stay, and inpatient and 30-day mortality were captured. Outcomes pre-NSECH and post-NSECH opening were compared and independent predictors of survival identified via logistic regression.

RESULTS

There were 6291 cases. 24/7 specialist emergency care was a strong independent predictor of lower mortality. Length of stay reduced by 1  day, but 90-day readmission rose in both ventilated and non-ventilated patients.

CONCLUSION

Provision of 24/7 respiratory specialist emergency care improved ECOPD survival and shortened length of stay for both non-ventilated and ventilated patients. The potential implications in respect to service design and provision nationally are substantial and challenging.

摘要

引言

在因慢性阻塞性肺疾病急性加重(ECOPD)而需住院治疗的患者中,更多地接触呼吸专科医生可改善治疗结果,但目前这一点并未始终得到落实。2015年英国全国患者治疗结果和死亡情况保密调查显示,超过25%接受急性无创通气(NIV)治疗的ECOPD患者在医院死亡。2015年6月16日,诺森比亚专科急救医院(NSECH)开业,引入了全天候的专科顾问随叫随到服务、从急诊科直接收治到专科病房以及7天的顾问复查。为需要NIV的患者开设了一个呼吸支持单元。在NSECH成立之前,NIV服务包括强制性培训和能力评估、全天候单点接入、在急诊科启动通气、门到面罩时间目标、通气压力的早期滴定以及结构化撤机。ECOPD合并肺炎或高碳酸血症昏迷从未被视为NIV的禁忌证。NSECH成立后,医护人员与患者的比例增加,NIV流程得到简化,并引入了结构化的每日多学科复查。我们将我们的治疗结果与历史数据和全国数据进行了比较。

方法

从编码中识别出2013年1月1日至2016年12月31日期间因ECOPD住院的患者,并从记录中确认通气状态和影像学实变情况。记录患者的年龄、性别、是否从养老院入院、实变情况、修订的查尔森指数、主要合并症、住院时间以及住院期间和30天死亡率。比较了NSECH开业前后的治疗结果,并通过逻辑回归确定了生存的独立预测因素。

结果

共有6291例病例。全天候专科急救是死亡率降低的有力独立预测因素。住院时间缩短了1天,但通气患者和未通气患者的90天再入院率均有所上升。

结论

提供全天候呼吸专科急救改善了ECOPD患者的生存率,并缩短了未通气和通气患者的住院时间。这对全国范围内的服务设计和提供可能产生的影响重大且具有挑战性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/89ba/6203006/15b003c26726/bmjresp-2018-000334f01.jpg

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