Morelli Fabrício, Souza Raquel Pantarotto, Cruz Taís Elisângela da, Damke Gabrielle Marconi Zago Ferreira, Damke Edilson, Suehiro Tamy Tuani, Silva Vânia Ramos Sela da, Consolaro Marcia Edilaine Lopes
Universidade Estadual de Maringá, Departamento de Análises Clínicas e Biomedicina, Programa de Pós-Graduação em Biociências e Fisiopatologia, Maringá, Paraná, Brazil.
Rev Inst Med Trop Sao Paulo. 2020 Mar 2;62:e16. doi: 10.1590/S1678-9946202062016. eCollection 2020.
This review provides a general overview on the positivity and persistence of Zika virus (ZIKV) in female genital tract (FGT) of non-pregnant women and animals, as well as in cell cultures, and its influence on FGT health. We performed a systematic review based on the PRISMA statement to identify studies focused on "Zika virus" and "non-pregnant female" in PubMed, Embase, Scopus Scholar and Web of Knowledge databases of full-text papers and abstracts published in English, with no restrictions regarding the initial date of publication, up to August 2019. Our search terms yielded 625 records, that were 108 after removal of duplicates, leaving 517 items for title and abstract reviews. Of these, 475 did not meet the inclusion criteria, leaving 42 records for full-text review and resulting in the exclusion of 6 additional records. The remaining 36 met our inclusion criteria. Variations were observed regarding the presence and persistence of ZIKV in lower and upper genital samples. However, the FGT was the place in which ZIKV RNA has been detected, sometimes for relatively long periods, even after the clearance from blood and urine. In addition to the vagina and cervix, the endometrium, uterus and ovary (oocytes and follicles) could also be involved in persistent ZIKV infections. Further prospective studies are needed to assess the effect of ZIKV on FGT health.
本综述概述了寨卡病毒（ZIKV）在非孕妇和动物的女性生殖道（FGT）以及细胞培养物中的阳性率和持续性，及其对FGT健康的影响。我们根据PRISMA声明进行了系统综述，以在PubMed、Embase、Scopus Scholar和Web of Knowledge数据库中识别聚焦于“寨卡病毒”和“非孕女性”的研究，这些数据库收录了以英文发表的全文论文和摘要，对首次发表日期无限制，截至2019年8月。我们的检索词产生了625条记录，去除重复项后为108条，剩下517项进行标题和摘要审查。其中，475项不符合纳入标准，剩下42条记录进行全文审查，又排除了6条记录。其余36条符合我们的纳入标准。在上下生殖道样本中寨卡病毒的存在和持续性方面观察到了差异。然而，FGT是检测到寨卡病毒RNA的部位，有时即使在血液和尿液中病毒清除后仍能检测到相对较长时间。除了阴道和宫颈外，子宫内膜、子宫和卵巢（卵母细胞和卵泡）也可能参与寨卡病毒的持续感染。需要进一步的前瞻性研究来评估寨卡病毒对FGT健康的影响。
