Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
Department of Food Science and Nutrition, Faculty of Human Life and Environment, Nara Women's University, Nara, Japan.
Eur J Cancer Prev. 2019 Sep;28(5):420-427. doi: 10.1097/CEJ.0000000000000491.
We aimed to assess the association between cruciferous vegetable intake and colorectal cancer (CRC) development among Japanese adults aged between 45 and 74 years in the Japan Public Health Center-based Prospective Study. During 1 325 853 person-years of follow-up, 2612 CRC cases were identified. The association of cruciferous vegetable intake with CRC risk was assessed using a Cox proportional hazard regression model to compute hazard ratios (HRs) and 95% confidence intervals (CIs), adjusted for potential confounders. No significant association was observed between the highest cruciferous vegetable intake quartile (compared with the lowest) and CRC risk in men (multivariate HRs: 1.08; 95% CI: 0.91, 1.29) and women (multivariate HRs: 0.99; 95% CI: 0.80, 1.22) and its subsites. Women showed a marginal negative association between cruciferous vegetable intake and the risk of colon cancer (CC) after excluding participants who developed CC in the first 3 years of follow-up (P for trend = 0.08); a positive association was found with proximal CC in men. Cruciferous vegetable intake does not have a significant association with CRC risk in the Japanese general population.
我们旨在评估日本成年人在 45 至 74 岁之间，十字花科蔬菜摄入量与结直肠癌（CRC）发展之间的关联。在 1325853 人年的随访期间，确定了 2612 例 CRC 病例。使用 Cox 比例风险回归模型评估十字花科蔬菜摄入量与 CRC 风险的相关性，计算风险比（HRs）和 95％置信区间（CIs），并调整了潜在的混杂因素。在男性（多变量 HRs：1.08；95％CI：0.91，1.29）和女性（多变量 HRs：0.99；95％CI：0.80，1.22）以及其亚部位中，最高十字花科蔬菜摄入量四分位数（与最低四分位数相比）与 CRC 风险之间没有明显关联。女性在排除随访头 3 年发生 CC 的参与者后，发现十字花科蔬菜摄入量与结肠癌（CC）的风险之间存在边缘负相关（趋势 P = 0.08）；而男性的近端 CC 与十字花科蔬菜摄入量呈正相关。十字花科蔬菜摄入量与日本普通人群的 CRC 风险无显著关联。
