Abe S K, Inoue M, Sawada N, Iwasaki M, Ishihara J, Sasazuki S, Shimazu T, Yamaji T, Shibuya K, Tsugane S
Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.
1] Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan [2] Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Tokyo 104-0045, Japan.
Br J Cancer. 2014 Mar 4;110(5):1316-21. doi: 10.1038/bjc.2013.799. Epub 2014 Jan 2.
Colorectal cancer (CRC) incidence rate increased rapidly in Japan between the 1950s and 1990s. We examined the association between rice intake and CRC risk in comparison with bread, noodles and cereal among Japanese adults enrolled in the Japan Public Health Center-based prospective Study.
A total of 73,501 Japanese men and women were followed-up from 1995 to 1999 until the end of 2008 for an average of 11 years. During 801,937 person-years of follow-up, we identified 1276 incident cases of CRC. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC for rice, noodle, bread and cereal intake were calculated by Cox proportional hazards model.
Overall, no significant association was observed for the highest quartile of rice intake compared with the lowest and the risk of CRC and its subsites in men (HR, 0.77; 95% CI, 0.56-1.07) and women (HR, 1.10; 95% CI, 0.71-1.68). However, a non-significant inverse trend was observed between rice intake and rectal cancer in men. No clear patterns of association were observed in bread, noodle and cereal intake.
Our findings suggest that the consumption of rice does not have a substantial impact on the risk of CRC in the Japanese population.
20世纪50年代至90年代期间，日本的结直肠癌（CRC）发病率迅速上升。在参加日本公共卫生中心前瞻性研究的日本成年人中，我们比较了大米摄入量与面包、面条和谷物摄入量，研究了它们与CRC风险之间的关联。
共有73501名日本男性和女性从1995年至1999年开始随访，直至2008年底，平均随访11年。在801937人年的随访期间，我们确定了1276例CRC新发病例。通过Cox比例风险模型计算大米、面条、面包和谷物摄入量的CRC风险比（HR）和95%置信区间（95%CI）。
总体而言，与最低摄入量相比，大米摄入量最高四分位数与CRC及其男性亚部位（HR，0.77；95%CI，0.56-1.07）和女性亚部位（HR，1.10；95%CI，0.71-1.68）的风险之间未观察到显著关联。然而，在男性中，大米摄入量与直肠癌之间观察到非显著的负相关趋势。在面包、面条和谷物摄入量方面未观察到明确的关联模式。
我们的研究结果表明，大米消费对日本人群的CRC风险没有实质性影响。
