六味地黄丸通过抑制α-淀粉酶和α-葡萄糖苷酶发挥抗糖尿病作用。
Liuwei Dihuang exhibits antidiabetic effects through inhibiting α-amylase and α-glucosidase.
作者信息
Wang Huafu, Gang Huang, Zhou Shuxin, Liu Lixian, Ding Ting, Gui Zhihong, Chu Weihua
机构信息
Department of pharmacy, Lishui People's Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China.
Department of Traditional Chinese Medicine, Lishui People's Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China.
出版信息
Med Sci (Paris). 2018 Oct;34 Focus issue F1:4-7. doi: 10.1051/medsci/201834f101. Epub 2018 Nov 7.
OBJECTIVE
Liuwei Dihuang (LWDH) is a famous traditional herbal medicine formula in China that may regulate the balance of kidney yin yang and has been used to restore functional insufficiency of the kidney for a long time in China.
METHODS
In this study, the water extract of LWDH was tested for its α-Amylase and α-Glucosidase inhibitory activities, and its anti-diabetic property in streptozotocin (STZ)-induced diabetic mice was also analyzed.
RESULTS
LWDH extract inhibited α-Glucosidase and α-Amylase activities in a dose- dependent manner. Treatment of streptozotocin-induced diabetic mice with LWDH extract decreased camp, fasting blood glucose, TC, TG, LDL-c, HbA1C, Urine volume levels and Urine sugar, increased HDL-c level when compared to STZ induced diabetic mice.
CONCLUSION
This study demonstrates that extract of LWDH can inhibit α-amylase and α-glucosidase activities and shows anti-diabetic effect in a mice preclinical model.
目的
六味地黄丸是中国著名的传统中药配方，可能调节肾阴阳平衡，在中国长期用于恢复肾脏功能不全。
方法
在本研究中，测试了六味地黄丸水提取物的α-淀粉酶和α-葡萄糖苷酶抑制活性，并分析了其在链脲佐菌素（STZ）诱导的糖尿病小鼠中的抗糖尿病特性。
结果
六味地黄丸提取物以剂量依赖性方式抑制α-葡萄糖苷酶和α-淀粉酶活性。与STZ诱导的糖尿病小鼠相比，用六味地黄丸提取物治疗链脲佐菌素诱导的糖尿病小鼠可降低cAMP、空腹血糖、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-c）、糖化血红蛋白（HbA1C）、尿量水平和尿糖，增加高密度脂蛋白胆固醇（HDL-c）水平。
结论
本研究表明，六味地黄丸提取物可抑制α-淀粉酶和α-葡萄糖苷酶活性，并在小鼠临床前模型中显示出抗糖尿病作用。
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