Murudkar Prajakta H, Tambe Mukul S, Chandrasekar S B, Boddeda Bhavani, Pawar Anil T
School of Pharmacy, Dr. Vishwanath Karad MIT World Peace University, Pune, India.
Drug Testing Laboratory, Drug Control Department, Bangalore, India.
Front Pharmacol. 2022 Oct 12;13:991083. doi: 10.3389/fphar.2022.991083. eCollection 2022.
Diabetes mellitus is the most widely recognized endocrine disorder which is influencing a bigger populace on the planet. There are various causes of diabetes, such as physical inactivity, obesity, family history, race, and age. Diabetes mellitus is associated with some life-threatening complications, such as neuropathy, nephropathy, various eye diseases or retinopathy, and cardiovascular disorders. Many synthetic antihyperglycemic agents are available in the market for the treatment of diabetes and its complications. But, due to some serious side effects of these synthetic agents, people are opting for herbal remedies and, therefore, they are now becoming popular. Herbal remedies have lesser side effects and higher affordability and therefore can be preferably used over synthetic agents for a long-term disorder like diabetes mellitus. In the present study, scientific research and review studies on the topic were collected from Science Direct, Scopus, PubMed, Google Scholar, and other relevant sources. The references of all the articles were screened manually for any additional information on popular polyherbal formulations in traditional Ayurvedic, Chinese, and Unani medicinal systems. It is found that these polyherbal formulations are studied for anti-diabetic potential. Furthermore, some are also investigated for mechanism of action of anti-diabetic effects. This review highlights various Ayurvedic, Chinese, and Unani polyherbal formulations commonly utilized in the management of diabetes mellitus along with their pre-clinical and clinical investigations, which will enhance the existing knowledge of the researchers.
糖尿病是最广为人知的内分泌疾病，影响着全球大量人口。糖尿病有多种病因，如缺乏运动、肥胖、家族病史、种族和年龄等。糖尿病与一些危及生命的并发症相关，如神经病变、肾病、各种眼部疾病或视网膜病变以及心血管疾病。市场上有许多合成抗高血糖药物可用于治疗糖尿病及其并发症。但是，由于这些合成药物存在一些严重的副作用，人们开始选择草药疗法，因此草药疗法现在越来越受欢迎。草药疗法副作用较小且价格更易承受，因此对于像糖尿病这样的长期疾病，相对于合成药物而言，更适合长期使用。在本研究中，从科学Direct、Scopus、PubMed、谷歌学术搜索和其他相关来源收集了关于该主题的科学研究和综述研究。人工筛选了所有文章的参考文献，以获取有关传统阿育吠陀、中医和尤纳尼医学体系中流行的多草药配方的任何其他信息。发现这些多草药配方已针对抗糖尿病潜力进行了研究。此外，一些配方还针对抗糖尿病作用的作用机制进行了研究。本综述重点介绍了常用于糖尿病管理的各种阿育吠陀、中医和尤纳尼多草药配方及其临床前和临床研究，这将增进研究人员现有的知识。
