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六味地黄丸通过抑制 TGF-/Smad2/3 通路减轻糖尿病肾病肾纤维化。

Liuwei Dihuang Pill Attenuates Diabetic Nephropathy by Inhibiting Renal Fibrosis via TGF-/Smad2/3 Pathway.

机构信息

Shanghai Punan Hospital of Pudong New District, Shanghai 200125, China.

Basic Medical School, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.

出版信息

Comput Math Methods Med. 2022 Mar 15;2022:5063636. doi: 10.1155/2022/5063636. eCollection 2022.

DOI:10.1155/2022/5063636
PMID:35341010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8941499/
Abstract

Among all the complications of diabetes, diabetic nephropathy is a significant factor causing the end-stage renal disease associated with high death rates. Current treatment fails to produce an ideal outcome. Thus, searching for a new preventive drug is urgently needed. Liuwei Dihuang pill (LDP), a popular ancient Chinese medicine (TCM) prescription, has been applied to treat DN-like syndromes according to TCM theory. Here, we had established an animal model with DN and LDP therapy was put into use to assess its therapeutic effect in vivo. Our data showed that oxidative stress and TGF-/Smad2/3 pathway-induced renal fibrosis could be observed in the DN animal model. However, the treatment of LDP impeded the generation of ROS and attenuated renal fibrosis-related proteins in damaged kidneys through interference in the TGF-/Smad3 pathway. Our results indicated that LDP attenuated oxidative stress, accompanied by preventing the production of renal fibrosis through inhibiting the TGF-/Smad2/3 pathway.

摘要

在糖尿病的所有并发症中，糖尿病肾病是导致与高死亡率相关的终末期肾病的重要因素。目前的治疗方法未能产生理想的效果。因此，迫切需要寻找一种新的预防药物。六味地黄丸（LDP）是一种流行的中药（TCM）方剂，根据中医理论已被用于治疗类似 DN 的综合征。在这里，我们建立了一个具有 DN 的动物模型，并使用 LDP 治疗来评估其体内的治疗效果。我们的数据表明，在 DN 动物模型中可以观察到氧化应激和 TGF-/Smad2/3 通路诱导的肾纤维化。然而，LDP 的治疗通过干扰 TGF-/Smad3 通路来抑制 ROS 的产生并减轻损伤肾脏中的肾纤维化相关蛋白。我们的结果表明，LDP 通过抑制 TGF-/Smad2/3 通路减轻氧化应激，同时防止肾纤维化的产生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b93/8941499/287300c34fb9/CMMM2022-5063636.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b93/8941499/fe2b43b88945/CMMM2022-5063636.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b93/8941499/c694cd68e63b/CMMM2022-5063636.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b93/8941499/3001c37a74b0/CMMM2022-5063636.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b93/8941499/287300c34fb9/CMMM2022-5063636.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b93/8941499/fe2b43b88945/CMMM2022-5063636.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b93/8941499/c694cd68e63b/CMMM2022-5063636.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b93/8941499/3001c37a74b0/CMMM2022-5063636.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b93/8941499/287300c34fb9/CMMM2022-5063636.004.jpg

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本文引用的文献

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Innate immunity in diabetic kidney disease.糖尿病肾病中的固有免疫。
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Long-term moderate intensity exercise alleviates myocardial fibrosis in type 2 diabetic rats via inhibitions of oxidative stress and TGF-β1/Smad pathway.长期中等强度运动通过抑制氧化应激和 TGF-β1/Smad 通路减轻 2 型糖尿病大鼠心肌纤维化。
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Liuwei Dihuang exhibits antidiabetic effects through inhibiting α-amylase and α-glucosidase.
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