Amsterdam UMC, Vrije Universiteit Amsterdam, VU University medical center, Department of Public and Occupational Health, de Boelelaan, Amsterdam, The Netherlands.
Amsterdam UMC, University of Amsterdam, Academic Medical Center, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Meibergdreef, Amsterdam, The Netherlands.
PLoS One. 2018 Nov 7;13(11):e0206888. doi: 10.1371/journal.pone.0206888. eCollection 2018.
Lifestyle changes are notoriously difficult. Since women who intend to become pregnant are more susceptible to lifestyle advice, interventions during this time window might be more effective than interventions during any other period in life. We here report the effects of the first large preconception lifestyle intervention RCT on diet and physical activity in obese infertile women.
In total, 577 women were randomized between a six-month lifestyle intervention program (intervention group; N = 290) or prompt infertility treatment (control group; N = 287). Self-reported dietary behaviors and physical activity were assessed at baseline, three, six and twelve months after randomization. Mixed models were used to analyze differences between groups.
Compared to the control group, the intervention group reduced their intake of sugary drinks at three months (-0.5 glasses/day [95% C.I. = -0.9;-0.2]), of savory snacks at three (-2.4 handful/week [-3.4;-1.4]) and at six months (-1.4 handful/week [-2.6;-0.2]), and of sweet snacks at three (-2.2 portion/week [-3.3;-1.0]) and twelve months after randomization (-1.9 portion/week [-3.5;-0.4]). Also, the intervention group was more moderate to vigorous physically active at three months after randomization compared to the control group (169.0 minutes/week [6.0; 332.1]).
Our study showed that obese infertile women who followed a six-month preconception lifestyle intervention program decreased their intake of high caloric snacks and beverages, and increased their physical activity. These changes in lifestyle may not only improve women's health but their offspring's health too.
生活方式的改变是出了名的困难。由于计划怀孕的女性更容易接受生活方式方面的建议，因此在此期间进行干预可能比在生命中的任何其他时期都更有效。我们在此报告首例针对肥胖不孕女性的饮食和体育活动的大型孕前生活方式干预 RCT 的结果。
共有 577 名女性被随机分为 6 个月的生活方式干预方案组（干预组；N=290）或即时不孕治疗组（对照组；N=287）。在随机分组后 3、6 和 12 个月时，使用混合模型分析了两组之间的差异。
与对照组相比，干预组在 3 个月时减少了含糖饮料的摄入量（-0.5 杯/天[95%置信区间=-0.9；-0.2]）、3 个月时（-2.4 把/周[-3.4；-1.4]）和 6 个月时（-1.4 把/周[-2.6；-0.2]）的咸味零食摄入量以及 3 个月时（-2.2 份/周[-3.3；-1.0]）和 12 个月时（-1.9 份/周[-3.5；-0.4]）的甜食摄入量。此外，与对照组相比，干预组在随机分组后 3 个月时进行了更多的中等至剧烈体力活动（169.0 分钟/周[6.0；332.1]）。
我们的研究表明，遵循 6 个月的孕前生活方式干预方案的肥胖不孕女性减少了高卡路里零食和饮料的摄入量，并增加了体力活动。这些生活方式的改变不仅可能改善女性的健康状况，还可能改善其后代的健康状况。
