Antimisiaris Sophia G, Mourtas Spyridon, Marazioti Antonia
Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, 26504 Rio-Patras, Greece.
Foundation for Research and Technology Hellas, Institute of Chemical Engineering, FORTH/ICE-HT, 26504 Rio-Patras, Greece.
Pharmaceutics. 2018 Nov 6;10(4):218. doi: 10.3390/pharmaceutics10040218.
The similarities between exosomes and liposomes, together with the high organotropism of several types of exosomes, have recently prompted the development of engineered-exosomes or exosome-mimetics, which may be artificial (liposomal) or cell-derived vesicles, as advanced platforms for targeted drug delivery. Here, we provide the current state-of-the-art of using exosome or exosome-inspired systems for drug delivery. We review the various approaches investigated and the shortcomings of each approach. Finally the challenges which have been identified to date in this field are summarized.
外泌体与脂质体之间的相似性，以及几种外泌体的高器官趋向性，最近促使了工程化外泌体或外泌体模拟物的发展，它们可以是人工（脂质体）或细胞衍生的囊泡，作为靶向药物递送的先进平台。在此，我们介绍了使用外泌体或受外泌体启发的系统进行药物递送的当前技术水平。我们回顾了所研究的各种方法以及每种方法的缺点。最后总结了该领域迄今为止已确定的挑战。
