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带状疱疹后神经痛患者脑电图中静息态γ振荡活动增强

Elevated Resting State Gamma Oscillatory Activities in Electroencephalogram of Patients With Post-herpetic Neuralgia.

作者信息

Zhou Rui, Wang Jing, Qi Wenjing, Liu Feng-Yu, Yi Ming, Guo Huailian, Wan You

机构信息

Neuroscience Research Institute, Peking University, Beijing, China.

Department of Neurobiology, School of Basic Medical Sciences, Beijing Institute For Brain Disorders, Capital Medical University, Beijing, China.

出版信息

Front Neurosci. 2018 Oct 23;12:750. doi: 10.3389/fnins.2018.00750. eCollection 2018.

DOI:10.3389/fnins.2018.00750
PMID:30405337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6205978/
Abstract

In acute and ongoing pain, the spontaneous oscillatory activity of electroencephalogram (EEG) has been characterized by suppression of alpha band oscillations and enhancement of gamma band oscillations. In pathological chronic pain which is more severe and common in clinic practice, it is of great interest to investigate the oscillatory activity especially at the broad gamma frequency bands. Our present study explored the resting state oscillatory activities of EEG in patients with post-herpetic neuralgia (PHN) over 3 months which is a typical neuropathic pain model in clinical researches. It was found that the PHN patients showed anxiety and depression revealed by Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) examinations. Power spectrum analysis revealed that the power at gamma frequency band (from 40 to 70 Hz) of EEG was significantly higher in the PHN patients, and positively correlated with pain intensity, anxiety, and depression indexes. Further, increased gamma activity derived from the prefrontal cortex and the cerebellum were revealed by cluster-based sensor level and the beamforming source level analyses. These results suggest the enhanced gamma oscillatory activity in the prefrontal cortex and cerebellum is a characteristic marker in chronic neuropathic pain patients.

摘要

在急性和持续性疼痛中，脑电图（EEG）的自发振荡活动表现为α波段振荡受到抑制，γ波段振荡增强。在临床实践中更为严重且常见的病理性慢性疼痛中，研究尤其是宽γ频段的振荡活动具有重要意义。我们目前的研究探讨了疱疹后神经痛（PHN）患者超过3个月的静息状态下EEG振荡活动，PHN是临床研究中的一种典型神经病理性疼痛模型。通过贝克焦虑量表（BAI）和贝克抑郁量表（BDI）检查发现，PHN患者表现出焦虑和抑郁。功率谱分析显示，PHN患者EEG的γ频段（40至70赫兹）功率显著更高，且与疼痛强度、焦虑和抑郁指标呈正相关。此外，基于聚类的传感器水平和波束形成源水平分析显示，前额叶皮质和小脑的γ活动增加。这些结果表明，前额叶皮质和小脑中增强的γ振荡活动是慢性神经病理性疼痛患者的一个特征性标志。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/312d020c4b22/fnins-12-00750-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/7d2d66e92c76/fnins-12-00750-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/42bc15e14362/fnins-12-00750-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/5e1b56b77e05/fnins-12-00750-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/33598c047b1d/fnins-12-00750-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/312d020c4b22/fnins-12-00750-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/7d2d66e92c76/fnins-12-00750-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/a3f2b73a61d5/fnins-12-00750-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/42bc15e14362/fnins-12-00750-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/5e1b56b77e05/fnins-12-00750-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/33598c047b1d/fnins-12-00750-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7bf/6205978/312d020c4b22/fnins-12-00750-g006.jpg

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