Gavurová Beáta, Kováč Viliam, Jarčušková Dominika
Faculty of Economics, Technical University of Košice, Košice, Slovakia.
Research and Innovation Centre Bioinformatics, University Science Park Technicom, Technical University of Košice, Košice, Slovakia.
Int J Alzheimers Dis. 2018 Oct 11;2018:3149495. doi: 10.1155/2018/3149495. eCollection 2018.
Alzheimer's disease-subsequently as AD in the text-represents a chronic neurodegenerative disease discussed very often in the recent period. It involves the G30 diagnosis expressing exactly AD and also the F00 diagnosis epitomising dementia in AD. The Slovak Republic has a very various population in terms of the disparities of the population localisation. The analysis is executed on the basement of the standardised mortality rate. It is calculated for the individual districts of the Slovak Republic to get a detailed spatial view and for each year of the explored period from 1996 to 2015 to get a time development. It has a considerably rising tendency. Therefore, the regional disparities of the standardised mortality rate of AD are analysed from an angle of view of its similarity, by its measurement in a form of a Euclidean distance approach. The results of the analysis offer the heat maps as the distance matrices in a graphic form and the maps of the individual districts too. These outputs reveal a very heterogeneous structure of the standardised mortality rate. Another graphic outcome demonstrates a distribution of its values among the districts throughout the whole Slovak Republic for the whole observed period. The results offer a comparison among the districts of the Slovak Republic too. The highest values and also the lowest values are reached in the different districts for the both sexes. Even, one district reaches the opposite result for the individual sexes. The age structure of the deceased population on the G30 diagnosis is also executed and the extreme values from an angle of a view of the districts are picked up. There are evident high differentiations between the individual districts of the Slovak Republic. The conclusion section involves the several key points and the potential suggestions for further research.
阿尔茨海默病（在本文中随后简称为AD）是一种近年来经常被讨论的慢性神经退行性疾病。它涉及明确表示AD的G30诊断以及体现AD痴呆症的F00诊断。就人口分布差异而言，斯洛伐克共和国人口构成非常多样化。分析是基于标准化死亡率进行的。计算斯洛伐克共和国各个地区的标准化死亡率，以获得详细的空间视图，并计算1996年至2015年探索期内每年的标准化死亡率，以了解其时间发展情况。其呈现出显著的上升趋势。因此，从相似性的角度，通过欧几里得距离法进行测量，分析AD标准化死亡率的地区差异。分析结果以图形形式提供了作为距离矩阵的热图以及各个地区的地图。这些输出结果揭示了标准化死亡率非常不均匀的结构。另一个图形结果展示了在整个观察期内其值在斯洛伐克共和国各地区之间的分布情况。结果还对斯洛伐克共和国各地区进行了比较。不同性别的最高值和最低值出现在不同的地区。甚至，在个别地区，不同性别的结果相反。还对G30诊断的死亡人口年龄结构进行了分析，并从地区角度选取了极值。斯洛伐克共和国各地区之间存在明显的高度差异。结论部分包含几个关键点以及对进一步研究的潜在建议。
