Dig Liver Dis. 2019 May;51(5):640-647. doi: 10.1016/j.dld.2018.09.026. Epub 2018 Oct 4.
The MARS-5 (Medication Adherence Report Scale) was developed in English. The aim of this project was to analyse the MARS-5I (© Prof Rob Horne) psychometric properties and to identify whether its Italian translation is suitable for assessing medication adherence in Crohn Disease (CD) Italian patients. The MARS was translated and linguistically validated in Italian. The MARS-5I was used for evaluating medication adherence in the SOLE study, conducted in Italy on 552 subjects with CD. In order to un-bias the questionnaire results from the effects of treatment change and/or effectiveness, the analyses were performed on the 277 patients whose disease activity remained stable, selected among the 371 patients who maintained the same treatment between two consecutive visits. Internal consistency was high (Cronbach's alpha of 0.86). Pearson's correlation coefficient was 0.50 (p<0.001) and 0.86 (p<0.001- outliers removed), indicating satisfactory test-retest. MARS 5I scores were not correlated with Treatment Satisfaction Questionnaire for Medication but a small and statistically significant correlation was shown with physician-evaluated medication adherence, indicating convergent validity. MARS-5I, the Italian translation of the English MARS, showed satisfactory internal consistency and test-retest, and a low but statistically significant convergent validity. We confirmed the utility of this tool in patients with CD.
MARS-5（用药依从性报告量表）最初以英文形式开发。本项目旨在分析 MARS-5I（©Rob Horne 教授）的心理测量特性，并确定其意大利语翻译是否适用于评估克罗恩病（CD）意大利患者的药物依从性。MARS 经过翻译和语言验证后被翻译成意大利语。MARS-5I 用于评估 SOLE 研究中 552 名 CD 患者的药物依从性，该研究在意大利进行。为了避免因治疗变化和/或疗效对问卷结果产生影响，对在两次连续就诊期间保持相同治疗的 371 名患者中选择的 277 名疾病活动稳定的患者进行了分析。内部一致性很高（Cronbach 的 alpha 为 0.86）。Pearson 相关系数为 0.50（p<0.001）和 0.86（p<0.001-删除异常值），表明测试-重测具有良好的相关性。MARS 5I 评分与药物治疗满意度问卷不相关，但与医生评估的药物依从性呈弱且具有统计学意义的相关性，表明具有收敛效度。MARS-5I（英文 MARS 的意大利语翻译）显示出良好的内部一致性和测试-重测，以及低但具有统计学意义的收敛效度。我们证实了该工具在 CD 患者中的实用性。
