Department of Clinical Pharmacy, Faculty of Pharmacy, Marmara University, Maltepe, Istanbul, Türkiye.
Department of Public Health, Faculty of Medicine, Marmara University, Maltepe, Istanbul, Türkiye.
Eur J Clin Pharmacol. 2024 Nov;80(11):1715-1723. doi: 10.1007/s00228-024-03735-0. Epub 2024 Aug 7.
The aim of this study was to evaluate the validity and reliability of the Turkish version of the Medication Practical Barriers to Adherence Questionnaire (MPRAQ-TR).
This is a validation study conducted between August 2022 and March 2023 in the ambulatory services of a secondary care private hospital located in Istanbul, Türkiye, among patients (18 years of age and older) with chronic diseases. After the Turkish translation and cultural adaptation of the MPRAQ, and a pilot think-aloud study, the following psychometric properties were assessed: internal consistency by calculating the Cronbach's alpha coefficient, 2-week test-retest reliability, convergent validity by calculating Spearman's rank correlation between the MPRAQ-TR and the Turkish version of Medication Adherence Report Scale (MARS), and predictive validity by evaluating the association between the MPRAQ-TR score and nonadherence to medications.
Among the 380 patients (response rate = 89.6%), 72.1% were nonadherent to their medications. The intraclass correlation coefficient was 0.99 for MPRAQ-TR scores (95% CI, 0.98-0.99; p < 0.001). The Cronbach's alpha of the MPRAQ-TR was 0.853. There was a moderate negative correlation between the scores on the MARS and the MPRAQ-TR (Spearman's rho = - 0.525; p < 0.01), supporting the convergent validity of the MPRAQ-TR. In the univariate analysis, the total score of MPRAQ-TR was associated with increased odds of nonadherence to medications (p < 0.01).
MPRAQ-TR shows good psychometric properties and can be used to evaluate the practical adherence barriers of patients with chronic diseases.
本研究旨在评估土耳其版药物实用遵医行为问卷（MPRAQ-TR）的有效性和可靠性。
这是一项验证性研究，于 2022 年 8 月至 2023 年 3 月在伊斯坦布尔一家二级私立医院的门诊服务中进行，纳入慢性病患者（18 岁及以上）。在 MPRAQ 进行土耳其语翻译和文化适应性调整以及试点出声思考研究后，评估了以下心理测量学特性：通过计算 Cronbach's alpha 系数评估内部一致性、2 周重测信度、通过计算 MPRAQ-TR 与土耳其版药物遵医行为报告量表（MARS）之间的 Spearman 秩相关系数评估聚合效度，以及通过评估 MPRAQ-TR 评分与药物不遵医行为之间的关联评估预测效度。
在 380 名患者中（应答率=89.6%），72.1%的患者不遵医嘱服药。MPRAQ-TR 评分的组内相关系数为 0.99（95%CI，0.98-0.99；p<0.001）。MPRAQ-TR 的 Cronbach's alpha 为 0.853。MARS 评分与 MPRAQ-TR 评分之间呈中度负相关（Spearman's rho=-0.525；p<0.01），支持 MPRAQ-TR 的聚合效度。在单变量分析中，MPRAQ-TR 的总分与药物不遵医行为的可能性增加相关（p<0.01）。
MPRAQ-TR 具有良好的心理测量学特性，可用于评估慢性病患者的实际遵医行为障碍。
