Ganga B, Wadud Abdul, Jahan Nasreen, Ajij Ahmed Makbul Shaikh
Department of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bengaluru, India.
Department of Ilmul Advia (Pharmacology), National Institute of Unani Medicine, Bengaluru, India.
J Ayurveda Integr Med. 2021 Jan-Mar;12(1):9-12. doi: 10.1016/j.jaim.2018.01.001. Epub 2018 Nov 7.
Habbe Gule Aakh is extensively used in Unani medicine for anti-inflammatory and analgesic activity.
To evaluate anti-inflammatory and analgesic effects of Habbe Gule Aakh on Wistar rats and Swiss mice of either sex.
The study was carried out in Wistar rats for anti-inflammatory activity while Swiss mice were used for analgesic activity. In both the tests animals were divided into five groups of six animals each which served as control, standard and test groups A, B and C. For anti-inflammatory activity, method reported by Amman was followed. For analgesic activity, Koster's protocol was adapted.
Significant (P < 0.01) reduction in the paw volume was noted in all the test groups but less than the standard drug. Mean writhes of group B and C reduced significantly (P < 0.01) demonstrating analgesic effect.
The study validated the claim of Unani medicine of use of Habbe Gule Aakh in inflammation and pain. Further, phytochemical studies are needed to know the exact mechanism of action of this formulation.
哈贝古勒阿克在尤纳尼医学中被广泛用于抗炎和镇痛。
评估哈贝古勒阿克对雄性和雌性Wistar大鼠及瑞士小鼠的抗炎和镇痛作用。
该研究在Wistar大鼠中进行抗炎活性实验，而在瑞士小鼠中进行镇痛活性实验。在这两项实验中，动物均被分为五组，每组六只，分别作为对照组、标准组以及实验组A、B和C。抗炎活性实验遵循阿曼报告的方法。镇痛活性实验采用科斯特的方案。
所有实验组的爪体积均显著（P < 0.01）减小，但小于标准药物组。B组和C组的平均扭体次数显著减少（P < 0.01），表明具有镇痛作用。
该研究证实了尤纳尼医学中使用哈贝古勒阿克治疗炎症和疼痛的说法。此外，需要进行植物化学研究以了解该制剂的确切作用机制。
