Program for Clinical Research, Department of Dermatology, University of California, San Francisco, San Francisco, California, USA.
Centre d'Infectiologie Necker-Pasteur, Paris, France.
J Invest Dermatol. 2019 Jan;139(1):13-16. doi: 10.1016/j.jid.2018.09.036. Epub 2018 Nov 8.
In November 2017, a formal debate on the role of bacteria in the pathogenesis of hidradenitis suppurativa (HS) was held at the 2nd Symposium on Hidradenitis Suppurativa Advances (SHSA) in Detroit, Michigan. In this report, we present both sides of the argument as debated at the SHSA meeting and then discuss the potential role of bacteria as classic infectious pathogens versus an alternative pathogenic role as activators of dysregulated commensal bacterial-host interactions. Although there was consensus that bacteria play a role in pathogenesis and thus are pathogenic, there was a compelling discussion about whether bacteria in HS incite an infectious disease as we classically understand it or whether bacteria might play a different role in HS pathogenesis.
2017 年 11 月，在密歇根州底特律举行的第二届化脓性汗腺炎进展研讨会（SHSA）上，就细菌在化脓性汗腺炎（HS）发病机制中的作用举行了一次正式辩论。在本报告中，我们展示了在 SHSA 会议上辩论的双方观点，然后讨论了细菌作为经典感染性病原体的潜在作用与失调的共生细菌-宿主相互作用的激活剂的替代致病作用。尽管大家一致认为细菌在发病机制中起作用，因此具有致病性，但关于 HS 中的细菌是否引发我们通常理解的传染病，还是细菌在 HS 发病机制中可能发挥不同作用，存在着激烈的讨论。
