布基纳法索KIR基因频率与慢性乙肝病毒感染之间相互作用的研究见解
Insights into the Interplay between KIR Gene Frequencies and Chronic HBV Infection in Burkina Faso.
作者信息
Sorgho Pegdwendé Abel, Martinson Jeremy James, Djigma Florencia Wendkuuni, Yonli Albert Théophane, Nagalo Bolni Marius, Compaore Tegwinde Rebeca, Obiri-Yeboah Dorcas, Diarra Birama, Sombie Herman Karim, Zongo Arsène Wendpagnangdé, Ouattara Abdoul Karim, Soubeiga Serge Théophile R, Traore Lassina, Roberts Lewis R, Simpore Jacques
机构信息
Laboratory of Molecular Biology and Genetics (LABIOGENE), University Ouaga I Prof. Joseph Ki-Zerbo, P.O. Box 7021, Ouagadougou 03, Burkina Faso.
Pietro Annigoni Biomolecular Research Center (CERBA), P.O. Box 364, Ouagadougou 01, Burkina Faso.
出版信息
Mediterr J Hematol Infect Dis. 2018 Nov 1;10(1):e2018060. doi: 10.4084/MJHID.2018.060. eCollection 2018.
BACKGROUND/OBJECTIVE: Hepatitis B virus (HBV) infection is the leading risk factor for cirrhosis and hepatocellular carcinoma (HCC). The objective of this investigation was to assess the association between "Killer Cell Immunoglobulin-Like Receptor" (KIR) gene frequencies and chronic HBV infection.
METHODS
Chronic HBV carriers and healthy patients were selected for this study. The viral load for HBV were performed, and SSP-PCR was used to characterize the frequencies of KIR genes.
RESULTS
The study suggested that inhibitory genes KIR2DL2 (crude OR = 2.82; p < 0.001), KIR2DL3 (crude OR = 2.49; p < 0.001) and activator gene KIR2DS2 (crude OR = 3.95; p< 0.001) might be associated with chronic stages of HBV infection. Conversely the inhibitory genes KIR3DL1 (crude OR = 0.49; p = 0.0018) and KIR3DL2 (crude OR = 0.41; p = 0.005), the activator gene KIR2DS1 (crude OR = 0.48; p = 0.014) and the pseudo gene KIR2DP1 (crude OR = 0.49; p = 0.008) could be associated with immunity against HBV infection. Chronic HBV patients who are carriers for the KIR3DL3 gene (crude OR = 8; p = 0.048) were positive for HBeAg and patients who carried the KIR3DL2 gene (crude OR = 3.21; p = 0.012) had a high HBV viral load compared to the rest of the study population.
CONCLUSION
Our data showed evidence of a correlation between the risk of developing chronic HBV infection and certain KIR gene frequencies and also show that KIR3DL1, KIR3DL2, KIR2DS1 might confer a protective status against chronic HBV infection.
背景/目的：乙型肝炎病毒（HBV）感染是肝硬化和肝细胞癌（HCC）的主要危险因素。本研究的目的是评估“杀伤细胞免疫球蛋白样受体”（KIR）基因频率与慢性HBV感染之间的关联。
方法
本研究选取慢性HBV携带者和健康患者。检测HBV病毒载量，并采用序列特异性引物聚合酶链反应（SSP-PCR）对KIR基因频率进行分析。
结果
研究表明，抑制性基因KIR2DL2（粗优势比=2.82；p<0.001）、KIR2DL3（粗优势比=2.49；p<0.001）和激活性基因KIR2DS2（粗优势比=3.95；p<0.001）可能与HBV感染的慢性阶段相关。相反，抑制性基因KIR3DL1（粗优势比=0.49；p = 0.0018）、KIR3DL2（粗优势比=0.41；p = 0.005），激活性基因KIR2DS1（粗优势比=0.48；p = 0.014）和假基因KIR2DP1（粗优势比=0.49；p = 0.008）可能与抗HBV感染免疫相关。携带KIR3DL3基因的慢性HBV患者（粗优势比=8；p = 0.048）HBeAg呈阳性，与其他研究人群相比，携带KIR3DL2基因的患者（粗优势比=3.21；p = 0.012）HBV病毒载量较高。
结论
我们的数据表明，慢性HBV感染风险与某些KIR基因频率之间存在相关性，并且表明KIR3DL1、KIR3DL2、KIR2DS1可能对慢性HBV感染具有保护作用。
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