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The renal handling of polybasic drugs. 1. Gentamicin and aprotinin in intact animals.

作者信息

Just M, Erdmann G, Habermann E

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;300(1):57-66. doi: 10.1007/BF00505080.

DOI:10.1007/BF00505080
PMID:304182
Abstract
摘要

相似文献

1
The renal handling of polybasic drugs. 1. Gentamicin and aprotinin in intact animals.
Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;300(1):57-66. doi: 10.1007/BF00505080.
2
The renal handling of polybasic drugs. 2. In vitro studies with brush border and lysosomal preparations.多元碱药物的肾脏处理。2. 刷状缘和溶酶体制剂的体外研究。
Naunyn Schmiedebergs Arch Pharmacol. 1977 Oct;300(1):67-76. doi: 10.1007/BF00505081.
3
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.上皮糖蛋白330/巨膜蛋白介导多碱性药物摄取的证据。
J Clin Invest. 1995 Sep;96(3):1404-13. doi: 10.1172/JCI118176.
4
Renal handling of gentamicin and other antibiotics by the isolated perfused rat kidney: mechanism of nephrotoxicity.
J Antimicrob Chemother. 1977 Nov;3(6):593-600. doi: 10.1093/jac/3.6.593.
5
Potentiation of gentamicin nephrotoxicity in the rat by infusion of aprotinin.通过输注抑肽酶增强庆大霉素对大鼠的肾毒性。
Exp Mol Pathol. 1994 Jun;60(3):197-213. doi: 10.1006/exmp.1994.1018.
6
The renal handling of biologically active peptides.
Contrib Nephrol. 1975;1:62-8. doi: 10.1159/000398229.
7
Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. I. Polyaspartic acid binds gentamicin and displaces it from negatively charged phospholipid layers in vitro.聚天冬氨酸对庆大霉素诱导的磷脂沉积症的保护机制。I. 聚天冬氨酸在体外结合庆大霉素并将其从带负电荷的磷脂层中置换出来。
J Pharmacol Exp Ther. 1990 Nov;255(2):867-74.
8
The epidermal growth factor precursor in the rat kidney seems to be processed by an aprotinin sensitive proteinase.
Agents Actions Suppl. 1992;38 ( Pt 2):183-90.
9
Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. II. Comparative in vitro and in vivo studies with poly-L-aspartic, poly-L-glutamic and poly-D-glutamic acids.聚天冬氨酸对庆大霉素诱导的磷脂沉积症的保护机制。II. 聚-L-天冬氨酸、聚-L-谷氨酸和聚-D-谷氨酸的体外和体内比较研究。
J Pharmacol Exp Ther. 1990 Nov;255(2):875-85.
10
Decreased fractional renal excretion of gentamicin in subtotal nephrectomized dogs.
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引用本文的文献

1
Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation.庆大霉素在经电穿孔处理的肾 LLC-PK1 细胞中，低浓度时会导致细胞凋亡。
Antimicrob Agents Chemother. 2006 Apr;50(4):1213-21. doi: 10.1128/AAC.50.4.1213-1221.2006.
2
Once daily aminoglycoside therapy. Is it less toxic than multiple daily doses and how should it be monitored?每日一次氨基糖苷类药物治疗。它的毒性是否低于每日多次给药，以及应如何进行监测？
Clin Pharmacokinet. 1999 Feb;36(2):89-98. doi: 10.2165/00003088-199936020-00001.
3
Daptomycin may attenuate experimental tobramycin nephrotoxicity by electrostatic complexation to tobramycin.

本文引用的文献

1
RAT-KIDNEY LYSOSOMES: ISOLATION AND PROPERTIES.大鼠肾脏溶酶体：分离与特性
Biochem J. 1965 Jun;95(3):731-41. doi: 10.1042/bj0950731.
2
PHARMACOLOGY OF GENTAMICIN, A NEW BROAD-SPECTRUM ANTIBIOTIC.新型广谱抗生素庆大霉素的药理学
Antimicrob Agents Chemother (Bethesda). 1963;161:138-47.
3
LYTIC ACTIVITIES IN RENAL PROTEIN ABSORPTION DROPLETS. AN ELECTRON MICROSCOPICAL CYTOCHEMICAL STUDY.肾蛋白吸收液滴中的溶解活性。一项电子显微镜细胞化学研究。
达托霉素可能通过与妥布霉素形成静电复合物来减轻实验性妥布霉素肾毒性。
Antimicrob Agents Chemother. 1994 Apr;38(4):742-9. doi: 10.1128/AAC.38.4.742.
4
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.上皮糖蛋白330/巨膜蛋白介导多碱性药物摄取的证据。
J Clin Invest. 1995 Sep;96(3):1404-13. doi: 10.1172/JCI118176.
5
Age-dependent nephrotoxicity and the pharmacokinetics of gentamicin in rats.庆大霉素在大鼠体内的年龄依赖性肾毒性及药代动力学
Eur J Pediatr. 1980;133(1):25-9. doi: 10.1007/BF00444750.
6
The pharmacological role of the kidney.肾脏的药理学作用。
Drugs. 1980 Jan;19(1):31-48. doi: 10.2165/00003495-198019010-00003.
7
Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: in vitro comparative studies.氨基糖苷类抗生素对溶酶体磷脂酶的抑制作用：体外比较研究。
Antimicrob Agents Chemother. 1983 Mar;23(3):440-9. doi: 10.1128/AAC.23.3.440.
8
Increased renal DNA synthesis in vivo after administration of low doses of gentamicin to rats.给大鼠注射低剂量庆大霉素后，其体内肾DNA合成增加。
Antimicrob Agents Chemother. 1983 Oct;24(4):586-93. doi: 10.1128/AAC.24.4.586.
9
Renal ultrastructural and biochemical injuries induced by aminoglycosides.氨基糖苷类药物引起的肾脏超微结构和生化损伤。
Environ Health Perspect. 1984 Aug;57:293-9. doi: 10.1289/ehp.8457293.
10
Determination of aminoglycosides in rat renal tissue by enzyme immunoassay.采用酶免疫分析法测定大鼠肾组织中的氨基糖苷类药物。
Antimicrob Agents Chemother. 1984 Apr;25(4):497-8. doi: 10.1128/AAC.25.4.497.
J Cell Biol. 1964 Dec;23(3):519-52. doi: 10.1083/jcb.23.3.519.
4
Rapid cytochemical identification of phagosomes in various tissues of the rat and their differentiation from mitochondria by the peroxidase method.通过过氧化物酶法对大鼠各种组织中的吞噬体进行快速细胞化学鉴定及其与线粒体的区分。
J Biophys Biochem Cytol. 1959 Mar 25;5(2):193-204. doi: 10.1083/jcb.5.2.193.
5
Cellular mechanisms of protein metabolism in the nephron. I. The structural aspects of proteinuria; tubular absorption, droplet formation, and the disposal of proteins.肾单位中蛋白质代谢的细胞机制。I. 蛋白尿的结构方面；肾小管吸收、液滴形成及蛋白质的处理。
J Exp Med. 1954 Jun 1;99(6):589-604. doi: 10.1084/jem.99.6.589.
6
Separation and properties of beta-galactosidase, beta-glucosidase, beta-glucuronidase and N-acetyl-beta-glucosaminidase from rat kidney.大鼠肾脏中β-半乳糖苷酶、β-葡萄糖苷酶、β-葡萄糖醛酸酶和N-乙酰-β-葡萄糖胺酶的分离及性质
Biochem J. 1967 Feb;102(2):525-32. doi: 10.1042/bj1020525.
7
Renal tubular protein absorption in the rat.大鼠肾小管对蛋白质的重吸收
J Clin Invest. 1970 Jan;49(1):1-4. doi: 10.1172/JCI106208.
8
Pharmacokinetics of gentamicin: distribution and plasma and renal clearance.庆大霉素的药代动力学：分布、血浆清除率和肾脏清除率
J Infect Dis. 1971 Dec;124 Suppl:S70-6. doi: 10.1093/infdis/124.supplement_1.s70.
9
[Renal excretion of gentamicin in man].[庆大霉素在人体中的肾脏排泄]
Dtsch Med Wochenschr. 1972 Oct 6;97(40):1496-8 passim. doi: 10.1055/s-0028-1107589.
10
[Protein absorption droplets and lysosomes in the proximal convoluted tubule of the rat kidney. Combined ectronmicroscopic and enzyme-cytochemical studies using intratubular injections with ferritin].[大鼠肾近端曲管中的蛋白质吸收液滴和溶酶体。使用铁蛋白进行肾小管内注射的电子显微镜和酶细胞化学联合研究]
Virchows Arch B Cell Pathol. 1970;5(2):124-43.