患有唐氏综合征的青少年的病史、认知和行为之间的关联：来自唐氏综合征认知项目的报告。
Associations Between Medical History, Cognition, and Behavior in Youth With Down Syndrome: A Report From the Down Syndrome Cognition Project.
机构信息
Tracie C. Rosser, Emory University; Jamie O. Edgin, University of Arizona; George T. Capone, Kennedy Krieger Institute; Debra R. Hamilton, Emory University; Emily G. Allen, Emory University; Kenneth J. Dooley, Emory University; Payal Anand, University of Arizona; John F. Strang, Children's National Medical Center; A. Chelsea Armour, Children's National Medical Center; Michelle A. Frank-Crawford, Kennedy Krieger Institute; Marie Moore Channell, MIND Institute; Elizabeth I. Pierpont, University of Wisconsin; Eleanor Feingold, University of Pittsburgh; Cheryl L. Maslen, Oregon Health & Science University; Roger H. Reeves, Johns Hopkins University; and Stephanie L. Sherman, Emory University.
出版信息
Am J Intellect Dev Disabil. 2018 Nov;123(6):514-528. doi: 10.1352/1944-7558-123.6.514.
The cause of the high degree of variability in cognition and behavior among individuals with Down syndrome (DS) is unknown. We hypothesized that birth defects requiring surgery in the first years of life (congenital heart defects and gastrointestinal defects) might affect an individual's level of function. We used data from the first 234 individuals, age 6-25 years, enrolled in the Down Syndrome Cognition Project (DSCP) to test this hypothesis. Data were drawn from medical records, parent interviews, and a cognitive and behavior assessment battery. Results did not support our hypothesis. That is, we found no evidence that either birth defect was associated with poorer outcomes, adjusting for gender, race/ethnicity, and socioeconomic status. Implications for study design and measurement are discussed.
唐氏综合征（DS）个体的认知和行为存在高度变异性，但病因尚不清楚。我们假设，在生命早期需要手术的出生缺陷（先天性心脏缺陷和胃肠道缺陷）可能会影响个体的功能水平。我们使用了来自唐氏综合征认知项目（DSCP）的前 234 名年龄在 6-25 岁的个体的数据来检验这一假设。数据来自病历、家长访谈以及认知和行为评估工具。结果并不支持我们的假设。也就是说，我们没有发现任何证据表明这两种出生缺陷与较差的结果相关，而是调整了性别、种族/民族和社会经济地位等因素。文章还讨论了研究设计和测量的意义。
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