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终生饮酒模式与国家酒精调查中糖尿病发病风险的关系。

Lifetime Alcohol Use Patterns and Risk of Diabetes Onset in the National Alcohol Survey.

机构信息

Alcohol Research Group , Public Health Institute, Emeryville, California.

Department of Social and Behavioral Sciences , School of Nursing, University of California, San Francisco, San Francisco, California.

出版信息

Alcohol Clin Exp Res. 2019 Feb;43(2):262-269. doi: 10.1111/acer.13924. Epub 2018 Dec 10.

Abstract

BACKGROUND

Studies of the role of alcohol use in diabetes risk have rarely included lifetime alcohol use measures, including the frequency of heavy occasions, or evaluated risks among Black or Hispanic respondents in US samples.

METHODS

Data from the 2014 to 2015 National Alcohol Survey of the U.S. population were used to estimate diabetes risk from drinking patterns at the time of onset in Cox proportional hazards models in a retrospective cohort design. Models for the population, males and females, and for White, Black, and Hispanic respondents of both genders were estimated using 2 versions of drinking pattern groupings at each age.

RESULTS

While a number of significant results were found with the first version of the drinking measures, we focus on those confirmed with measures from responses strictly prior to the age of risk estimation. Compared to the lifetime abstainer group, the "drinking at least weekly with less than monthly 5+" group had a significantly lower hazard ratio (HR) for the total sample (HR = 0.64) and among Whites (HR = 0.42). Significantly reduced risks were found in the same models for those who drank 5+ at least monthly but not weekly. No significantly elevated risks were found for either current or prior heavy occasion drinking.

CONCLUSIONS

These results are consistent with some prior studies in finding reduced risks for regular light-to-moderate drinkers, but not consistent with findings from other studies showing increased risk from heavy occasion drinking, particularly among women. New and larger studies with well-defined drinking pattern measures are needed, particularly for U.S. Blacks and Hispanics, to address varying results in this literature.

摘要

背景

研究饮酒与糖尿病风险的关系时,很少有研究包含终生饮酒量的测量,包括重度饮酒的频率,也很少有研究在美国人群样本中评估黑人和西班牙裔受访者的风险。

方法

使用美国人群 2014 年至 2015 年全国酒精调查的数据,采用回顾性队列设计中的 Cox 比例风险模型,根据发病时的饮酒模式来估计糖尿病风险。在人群、男性和女性以及白种人、黑人和西班牙裔男女受访者中,使用两种版本的饮酒模式分组,在每个年龄组估计模型。

结果

尽管在第一种饮酒测量方法中发现了一些显著的结果,但我们重点关注那些通过在风险估计年龄之前严格回答的测量结果所证实的结果。与终生不饮酒者相比,“至少每周饮酒但每月饮酒少于 5 次且每次饮酒 5 单位以上”组的总样本(HR=0.64)和白种人(HR=0.42)的危险比(HR)显著降低。在相同模型中,那些每月至少饮酒 5 次但不每周饮酒的人,风险也显著降低。对于当前或既往重度饮酒者,未发现风险显著升高。

结论

这些结果与一些先前研究发现的规律轻度至中度饮酒者风险降低的结果一致,但与其他研究显示重度饮酒者风险增加的结果不一致,尤其是对于女性。需要进行新的、更大的、有明确饮酒模式测量的研究,特别是针对美国黑人和西班牙裔人群,以解决该文献中存在的不同结果。

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