School of Chemistry, Alborz Campus, University of Tehran, Tehran, Iran.
School of Chemistry, Alborz Campus, University of Tehran, Tehran, Iran.
Mater Sci Eng C Mater Biol Appl. 2019 Jan 1;94:445-452. doi: 10.1016/j.msec.2018.09.058. Epub 2018 Sep 22.
In this work, the anti-bacterial effect of Aloe vera derivate fibers produced by the electrospinning method was reported. Aloe vera Polyvinylpyrrolidone (Av/PVP) and Aloe vera acetate-Polyvinylpyrrolidone (AvAc/PVP) electrospun fibers were prepared with different concentrations and their microstructure and mechanical properties were studied. Various methods such as differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), water contact angle (CA) tests, Fourier-Transform Nuclear Magnetic Resonance (FT-NMR), scanning electron microscope (SEM), X-ray diffraction (XRD), CHNSO and Fourier-Transform Infrared Spectroscopy (FT-IR) were used to characterize prepared samples. (Av/PVP) electrospun fibers were prepared with different concentrations (6-10 wt%) of PVP and 0.2 wt% Av blended and tested in medicinal herb for wound healing, antibacterial and anti-inflammatory properties. For further study, the effect of AvAc film on the properties of composite film was studied. AvAc increased the thermal stability and crystallite size percentage of samples. Antibacterial and antiviral test studies on the scaffold displayed no bacterial and viral growth. These results suggest that AvAc/PVP scaffolds could be promising candidates for wound healing applications.
本工作报道了电纺法制备的芦荟衍生物纤维的抗菌效果。采用不同浓度的芦荟-聚乙烯吡咯烷酮（Av/PVP）和芦荟乙酸-聚乙烯吡咯烷酮（AvAc/PVP）制备了电纺纤维，并对其微观结构和力学性能进行了研究。采用差示扫描量热法（DSC）、热重分析（TGA）、水接触角（CA）测试、傅里叶变换核磁共振（FT-NMR）、扫描电子显微镜（SEM）、X 射线衍射（XRD）、CHNSO 和傅里叶变换红外光谱（FT-IR）等各种方法对制备的样品进行了表征。（Av/PVP）电纺纤维采用不同浓度（6-10wt%）的 PVP 和 0.2wt%Av 混合制备，并在草药中进行了伤口愈合、抗菌和抗炎性能测试。为进一步研究，研究了 AvAc 薄膜对复合膜性能的影响。AvAc 提高了样品的热稳定性和结晶度百分比。支架的抗菌和抗病毒测试研究显示没有细菌和病毒生长。这些结果表明，AvAc/PVP 支架可能是伤口愈合应用的有前途的候选物。
