Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Molecular Microbiology, Oslo University Hospital, Oslo, Norway.
Dis Markers. 2018 Oct 23;2018:1236837. doi: 10.1155/2018/1236837. eCollection 2018.
Serum uric acid (UA) is the final product of purine metabolism in humans. The present study is aimed at identifying the potential association between serum UA and early-onset coronary artery disease (EOCAD). The study population consisted of 1093 EOCAD patients aged ≤50 years, and 1117 age- and sex-matched apparently healthy people served as controls. The concentrations of UA were measured by uricase method. The severity of CAD was evaluated by Gensini score. The mean serum level of UA was 5.843 ± 1.479 mg/dl in EOCAD patients and 5.433 ± 1.529 mg/dl in controls. Serum UA levels were significantly higher in the EOCAD group than those in the control group ( < 0.001) and was an independent risk factor for EOCAD (OR = 1.100, 95% CI: 1.022-1.185). The early-onset myocardial infarction patients with 3-vessel disease had higher serum UA levels than those with 1- or 2-vessel disease. The serum UA levels of EOCAD patients with acute coronary syndrome were significantly higher than those with chronic coronary artery disease. EOCAD patients with hyperuricemia had higher Gensini scores than those without hyperuricemia. In addition, the serum UA levels were affected by drinking ( < 0.01) and were positively correlated with serum creatinine ( = 0.323) and weight ( = 0.327). Our results show that serum UA was an independent risk factor for EOCAD. The serum UA levels were associated with the presence and severity of EOCAD and suggested that UA may be involved in the progression of EOCAD.
血清尿酸（UA）是人类嘌呤代谢的终产物。本研究旨在确定血清 UA 与早发冠状动脉疾病（EOCAD）之间的潜在关联。研究人群包括 1093 名年龄≤50 岁的 EOCAD 患者和 1117 名年龄和性别匹配的健康对照者。UA 浓度采用尿酸酶法测定。CAD 的严重程度通过 Gensini 评分评估。EOCAD 患者的平均血清 UA 水平为 5.843±1.479mg/dl，对照组为 5.433±1.529mg/dl。EOCAD 组血清 UA 水平明显高于对照组（<0.001），且是 EOCAD 的独立危险因素（OR=1.100，95%CI：1.022-1.185）。三支病变的早发心肌梗死患者血清 UA 水平高于一支或两支病变患者。急性冠状动脉综合征 EOCAD 患者的血清 UA 水平明显高于慢性冠状动脉疾病患者。高尿酸血症的 EOCAD 患者的 Gensini 评分高于无高尿酸血症的患者。此外，血清 UA 水平受饮酒影响（<0.01），与血清肌酐（=0.323）和体重（=0.327）呈正相关。我们的研究结果表明，血清 UA 是 EOCAD 的独立危险因素。血清 UA 水平与 EOCAD 的存在和严重程度有关，提示 UA 可能参与了 EOCAD 的进展。
