主动脉平滑肌细胞的异质性：胸主动脉瘤区域特征的决定因素？ - Suppr

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Heterogeneity of Aortic Smooth Muscle Cells: A Determinant for Regional Characteristics of Thoracic Aortic Aneurysms?

作者信息

Sawada Hisashi, Chen Jeff Z, Wright Bradley C, Sheppard Mary B, Lu Hong S, Daugherty Alan

机构信息

Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA.

Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.

出版信息

J Transl Int Med. 2018 Oct 9;6(3):93-96. doi: 10.2478/jtim-2018-0023. eCollection 2018 Sep.

DOI:10.2478/jtim-2018-0023

PMID:30425944

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6231305/

Abstract

摘要

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Heterogeneity of Aortic Smooth Muscle Cells: A Determinant for Regional Characteristics of Thoracic Aortic Aneurysms?主动脉平滑肌细胞的异质性：胸主动脉瘤区域特征的决定因素？

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Aortic microcalcification is associated with elastin fragmentation in Marfan syndrome.主动脉微钙化与马凡综合征中的弹性蛋白断裂有关。

J Pathol. 2017 Nov;243(3):294-306. doi: 10.1002/path.4949. Epub 2017 Sep 21.

Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta-Brief Report.源自第二心脏场和心脏神经嵴的平滑肌细胞位于升主动脉中膜的不同空间区域——简要报告

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1722-1726. doi: 10.1161/ATVBAHA.117.309599. Epub 2017 Jun 29.

Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events.平滑肌细胞特异性Tgfbr1缺陷通过刺激多种信号事件促进主动脉瘤形成。

Sci Rep. 2016 Oct 14;6:35444. doi: 10.1038/srep35444.

Ascending Aortic Aneurysm in Angiotensin II-Infused Mice: Formation, Progression, and the Role of Focal Dissections.血管紧张素 II 输注小鼠升主动脉瘤的形成、进展及局灶性夹层的作用

Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):673-81. doi: 10.1161/ATVBAHA.116.307211. Epub 2016 Feb 18.

Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice.产后平滑肌细胞中II型转化生长因子-β受体的缺失导致小鼠严重主动脉病变。

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2647-56. doi: 10.1161/ATVBAHA.115.306573. Epub 2015 Oct 22.

Syphilis as a Cause of Thoracic Aortic Aneurysm.梅毒作为胸主动脉瘤的一个病因

Am J Cardiol. 2015 Oct 15;116(8):1298-303. doi: 10.1016/j.amjcard.2015.07.030. Epub 2015 Jul 28.

Dimorphic effects of transforming growth factor-β signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome.转化生长因子-β信号在小鼠主动脉瘤进展过程中的双相作用提示了马凡综合征的联合治疗方案。

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):911-7. doi: 10.1161/ATVBAHA.114.305150. Epub 2015 Jan 22.

Hypertension overrides the protective effect of female hormones on the development of aortic aneurysm secondary to Alk5 deficiency via ERK activation.高血压通过激活细胞外信号调节激酶（ERK），消除了女性激素对因激活素受体样激酶5（Alk5）缺乏继发的主动脉瘤形成的保护作用。

Am J Physiol Heart Circ Physiol. 2015 Jan 15;308(2):H115-25. doi: 10.1152/ajpheart.00521.2014. Epub 2014 Nov 14.

Thoracic aortic aneurysm and dissection.胸主动脉瘤和夹层。

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Angiotensin II induces region-specific medial disruption during evolution of ascending aortic aneurysms.在升主动脉瘤的发展过程中，血管紧张素II会引发特定区域的中膜破坏。

Am J Pathol. 2014 Sep;184(9):2586-95. doi: 10.1016/j.ajpath.2014.05.014. Epub 2014 Jul 16.

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