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炎症反应基因多态性与儿童急性肾损伤风险的关联。

Association between inflammatory-response gene polymorphisms and risk of acute kidney injury in children.

机构信息

Department of Pediatrics, The First People's Hospital of Bijie, Bijie 551700, Guizhou Province, China.

Department of Radiology, The First People's Hospital of Bijie, Bijie 551700, Guizhou Province, China.

出版信息

Biosci Rep. 2018 Dec 14;38(6). doi: 10.1042/BSR20180537. Print 2018 Dec 21.

DOI:10.1042/BSR20180537
PMID:30429237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6294618/
Abstract

In the present study, we investigated the association of 12 polymorphisms in six inflammatory-response genes ( and ) with risk of acute kidney injury (AKI) in children. The polymorphisms were genotyped in 1138 children with AKI and 1382 non-AKI controls. Logistic regression analysis was performed to calculate the odds ratio for estimating the risk association. After accounting for Bonferroni correction and adjustment for potential confounders, significant association was observed for rs28362491, rs2233406 and rs696 polymorphisms ( < 0.004). All three polymorphisms were associated with a reduced risk of AKI. For rs28362491 polymorphism, the OR for ID vs. II comparison was 0.75 (95% CI = 0.58-0.83) while that for DD vs. II was 0.44 (95% CI = 0.30-0.67). For rs2233406 polymorphism, the CT vs. CC comparison showed an OR of 0.90 (95% CI = 0.39-0.99), while the TT vs. CC comparison showed an OR of 0.43 (95% CI = 0.33-0.80). For rs696 polymorphism, the OR for AG vs. AA comparison was 0.71 (95% CI = 0.43-0.89), while the GG vs. AA comparison showed an OR of 0.39 (95% CI = 0.21-0.71). In conclusion, rs28362491, rs2233406 and rs696 polymorphisms may serve as biomarkers for predicting risk of AKI in children.

摘要

在本研究中，我们研究了六个炎症反应基因（和）中的 12 个多态性与儿童急性肾损伤（AKI）风险的关联。在 1138 名 AKI 患儿和 1382 名非 AKI 对照中对多态性进行了基因分型。使用逻辑回归分析计算了估计风险关联的比值比。在考虑 Bonferroni 校正和调整潜在混杂因素后，观察到 rs28362491、rs2233406 和 rs696 多态性与 AKI 风险显著相关（<0.004）。所有三个多态性均与 AKI 风险降低相关。对于 rs28362491 多态性，与 II 相比，ID 的 OR 为 0.75（95%CI=0.58-0.83），而与 II 相比，DD 的 OR 为 0.44（95%CI=0.30-0.67）。对于 rs2233406 多态性，CT 与 CC 比较的 OR 为 0.90（95%CI=0.39-0.99），而 TT 与 CC 比较的 OR 为 0.43（95%CI=0.33-0.80）。对于 rs696 多态性，AG 与 AA 比较的 OR 为 0.71（95%CI=0.43-0.89），而 GG 与 AA 比较的 OR 为 0.39（95%CI=0.21-0.71）。总之，rs28362491、rs2233406 和 rs696 多态性可作为预测儿童 AKI 风险的生物标志物。