Brito Aline de Freitas, Silva Alexandre S, de Souza Alesandra A, Ferreira Paula B, de Souza Iara L L, Araujo Layanne C da Cunha, Félix Gustavo da Silva, Sampaio Renata de Souza, Silva Maria da Conceição C, Tavares Renata L, Pereira Reabias de Andrade, Miranda Neto Manoel, da Silva Bagnólia A
School of Physical Education, University of Pernambuco, Recife, Brazil.
Post-Graduation Program in Physical Education UPE/UFPB, Recife, Brazil.
Front Physiol. 2018 Oct 31;9:1522. doi: 10.3389/fphys.2018.01522. eCollection 2018.
Studies have shown that supplementation with improves vascular reactivity. However, it is unclear whether in association with strength training this effect can be enhanced. Thus, this study aimed to determine the effects of strength training and on the reactivity of the aorta from Wistar rat and the possible mechanisms involved. The animals were supplemented with and divided into sedentary (SG, SG50, SG150, and SG500) and trained groups (TG, TG50, TG150, and TG500). Nitrite, malondialdehyde (MDA) and antioxidant activity were determined by biochemical assays. To evaluate vascular response, cumulative concentration-response curves to phenylephrine (PHE) and acetylcholine (ACh) were constructed. L-NAME was used to assess the participation of nitric oxide (NO). It was observed that the PHE contractile potency was reduced in TG50, TG150, and TG500 groups compared to SG50, SG150, and SG500 groups, respectively. However, the presence of L-NAME increased the contractile response in all groups. Strength training potentiated the increase in relaxing activity induced by , where the pCE values of ACh increased in TG150 and TG500. These responses were accompanied by increased nitrite production, MDA reduction and increased antioxidant activity in the aorta of both TG150 and TG500 groups. Thus, the present study demonstrated that combined with strength training, potentiates vascular improvement through the participation of NO and reduction of oxidative stress.
研究表明，补充[具体物质未给出]可改善血管反应性。然而，尚不清楚与力量训练相结合时，这种效果是否会增强。因此，本研究旨在确定力量训练和[具体物质未给出]对Wistar大鼠主动脉反应性的影响以及可能涉及的机制。给动物补充[具体物质未给出]，并分为久坐组（SG、SG50、SG150和SG500）和训练组（TG、TG50、TG150和TG500）。通过生化分析测定亚硝酸盐、丙二醛（MDA）和抗氧化活性。为评估血管反应，构建了对去氧肾上腺素（PHE）和乙酰胆碱（ACh）的累积浓度-反应曲线。使用L-精氨酸甲酯（L-NAME）评估一氧化氮（NO）的参与情况。观察到，与SG50、SG150和SG500组相比，TG50、TG150和TG500组中PHE的收缩效力分别降低。然而，L-NAME的存在增加了所有组的收缩反应。力量训练增强了由[具体物质未给出]诱导的舒张活性增加，其中TG150和TG500组中ACh的pCE值增加。这些反应伴随着TG150和TG500组主动脉中亚硝酸盐产生增加、MDA减少和抗氧化活性增加。因此，本研究表明，与力量训练相结合，[具体物质未给出]通过NO的参与和氧化应激的减少来增强血管改善。
