幽门螺杆菌感染与中风的患病率。

Helicobacter pylori infection and prevalence of stroke.

机构信息

Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Medical Division, Maccabi Health Services, Tel Aviv, Israel.

出版信息

Helicobacter. 2019 Feb;24(1):e12553. doi: 10.1111/hel.12553. Epub 2018 Nov 15.

DOI:10.1111/hel.12553

PMID:30431685

Abstract

BACKGROUND

Helicobacter pylori causes peptic ulcer disease; however, conflicting evidence exists regarding its role in extragastric conditions. We aimed to examine associations of H pylori infection and peptic ulcer disease with stroke.

METHODS

A cross-sectional study was undertaken using data of 147 936 individuals aged 25-95 years who underwent the urea breath test during 2002-2012, based on the computerized database of the second largest health maintenance organization in Israel. Logistic regression models were fitted to control for potential confounders.

RESULTS

Overall, 1397 (0.9%) patients had stroke and 76 965 (52.0%) had a H pylori positive test. The likelihood of prevalent stroke increased in relation to H pylori infection: adjusted odds ratio (aOR) 1.16 (95% confidence intervals [CI]: 1.04-1.29), gastric ulcer: aOR 1.50 (95% CI: 1.18-1.91), and duodenal ulcer: aOR 1.25 (95% CI: 1.07-1.46).

CONCLUSIONS

The results support the premise that stroke may be associated with a history of H pylori infection.

摘要

背景

幽门螺杆菌可导致消化性溃疡病；然而，其在胃肠外疾病中的作用存在相互矛盾的证据。我们旨在研究幽门螺杆菌感染和消化性溃疡病与中风之间的关联。

方法

本研究采用了基于以色列第二大健康维护组织的计算机化数据库，在 2002 年至 2012 年间进行尿素呼气试验的 147936 名 25-95 岁个体的横断面研究数据。采用逻辑回归模型控制潜在混杂因素。

结果

总体而言，1397 名（0.9%）患者患有中风，76965 名（52.0%）幽门螺杆菌检测呈阳性。与幽门螺杆菌感染相关，中风的发病可能性增加：调整后的优势比（aOR）为 1.16（95%置信区间[CI]：1.04-1.29），胃溃疡：aOR 为 1.50（95% CI：1.18-1.91），十二指肠溃疡：aOR 为 1.25（95% CI：1.07-1.46）。