Onik G, Porterfield B, Rubinsky B, Cohen J
Department of Radiology, Presbyterian-University Hospital, Pittsburgh, Pennsylvania.
Urology. 1991 Mar;37(3):277-81. doi: 10.1016/0090-4295(91)80306-r.
Cryosurgery has previously been used successfully to treat prostatic carcinoma. Inability to monitor the freezing led to local complications that limited the use of this modality. Recent studies have shown that monitoring of the freezing process can be accomplished using real-time ultrasound. In this study, transrectal ultrasound guidance was used to guide a cryoprobe percutaneously, using a transperineal approach, into the prostate. The extent of freezing was then monitored using ultrasound, taking care not to freeze the urethra or the rectum. Six dogs had the procedure without any complications. This study demonstrates the feasibility of a noninvasive treatment for prostatic carcinoma.
冷冻手术此前已成功用于治疗前列腺癌。由于无法监测冷冻过程，导致出现局部并发症，限制了这种治疗方式的应用。最近的研究表明，使用实时超声可以实现对冷冻过程的监测。在本研究中，采用经会阴途径，经直肠超声引导经皮将冷冻探头插入前列腺。然后用超声监测冷冻范围，注意避免冷冻尿道或直肠。6只犬接受了该手术，未出现任何并发症。本研究证明了前列腺癌无创治疗的可行性。
