Jelbuldina Madina, Korganbayev Sanzhar, Korobeinyk Alina V, Inglezakis Vassilis J, Tosi Daniele
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8513227.
In this paper, we present real-time profiles of temperature during a ferromagnetic nanoparticles (NPs)enhanced radiofrequency ablation (RFA). A minimally invasive RFA setup has been prepared and applied ex vivo on a liver phantom; NPs (with concentration of 5 mg/mL) have been synthetized and injected within the tissue prior to perform the ablation, in order to facilitate the heat distribution to the peripheral sides of the ablated tissue. Temperature detection has been realized in situ with a network of 15 fiber Bragg grating (FBG) sensors in order to highlight the impact of the NPs on the RFA mechanism. Obtained temperature profiles and thermal maps confirm that nanoparticles injection ensures better heat penetration than in case of pristine RFA procedure. The results show that adding NPs solution leads to extending the successfully ablated area achieving a double-sized lesion.
在本文中，我们展示了铁磁性纳米颗粒（NPs）增强射频消融（RFA）过程中的实时温度曲线。我们制备了一种微创RFA装置，并在离体肝脏模型上进行了应用；已合成浓度为5 mg/mL的NPs，并在进行消融之前将其注入组织内，以促进热量向消融组织周边的分布。通过由15个光纤布拉格光栅（FBG）传感器组成的网络实现了原位温度检测，以突出NPs对RFA机制的影响。获得的温度曲线和热图证实，与原始RFA程序相比，注射纳米颗粒可确保更好的热穿透。结果表明，添加NPs溶液可扩大成功消融区域，形成双倍大小的病灶。
