Meroni Davide, Bovio Dario, Gualtieri Massimo, Aliverti Andrea
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8513502.
The electrical properties of biological tissues differ depending on their structural characteristics. In literature, a lot of study have been carried out with the intent of taking advantage of bioimpedance analysis. Unfortunately, many apparatuses used during these evaluations were not always designed for measurements on living tissues. As a consequence, data could be affected by electrode polarization. In 2016, we presented a new impedance meter, developed for measurements on living tissues. Initially, it was tested only on ex-vivo rabbit's tissues with promising results. As a continuation, this device has been tested on in-vivo samples by placing a needle-probe into 3 tissues (liver, spleen, ovary) of 2 female dogs. Furthermore, was evaluated also the bioimpedance signal of the ovary explanted, comparing it with the in-vivo data. Bioimpedance was analyzed in terms of modulus and phase along a broad spectrum of frequencies (10Hz - 10kHz).Data obtained confirm the possibility of discriminating among the 3 tested tissues, at high frequencies for modulus and at low for phase. Confirmation that values on in-vivo and exvivo tissues are comparable if detected within few minutes after the explant, is also reported. We conclude that this clinical evaluation confirmed, also in-vivo, the good performance of the device previously tested on ex-vivo tissues, and provide more information about the tissue properties and characteristics.
生物组织的电学特性因其结构特征而异。在文献中，为了利用生物阻抗分析已开展了大量研究。不幸的是，这些评估中所使用的许多仪器并非总是为在活体组织上进行测量而设计的。因此，数据可能会受到电极极化的影响。2016年，我们推出了一种新的阻抗计，专为在活体组织上进行测量而开发。最初，它仅在离体兔组织上进行了测试，结果很有前景。作为后续工作，该设备已通过将针式探头插入2只雌性犬的3种组织（肝脏、脾脏、卵巢）中在活体样本上进行了测试。此外，还对摘除的卵巢的生物阻抗信号进行了评估，并将其与活体数据进行了比较。在10Hz - 10kHz的宽频率范围内对生物阻抗的模量和相位进行了分析。获得的数据证实了在高频下根据模量以及在低频下根据相位区分3种测试组织的可能性。还报告了如果在摘除后几分钟内进行检测，活体组织和离体组织上的值具有可比性的确认结果。我们得出结论，这项临床评估在活体中也证实了该设备先前在离体组织上测试时的良好性能，并提供了有关组织特性和特征的更多信息。
